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ADGRG7 adhesion G protein-coupled receptor G7 [ Homo sapiens (human) ]

Gene ID: 84873, updated on 22-Sep-2022

Summary

Official Symbol
ADGRG7provided by HGNC
Official Full Name
adhesion G protein-coupled receptor G7provided by HGNC
Primary source
HGNC:HGNC:19241
See related
Ensembl:ENSG00000144820 MIM:612307; AllianceGenome:HGNC:19241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR128
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum (RPKM 18.5), small intestine (RPKM 17.4) and 2 other tissues See more
Orthologs
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Genomic context

See ADGRG7 in Genome Data Viewer
Location:
3q12.2
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100609601..100695479)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103315353..103401238)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100328445..100414323)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene leukemia NUP98 fusion partner 1 Neighboring gene transmembrane protein 45A Neighboring gene glia maturation factor beta pseudogene 1 Neighboring gene trafficking from ER to golgi regulator Neighboring gene uncharacterized LOC124906260 Neighboring gene ABI family member 3 binding protein Neighboring gene Sharpr-MPRA regulatory region 7106

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ14454, FLJ16382, FLJ29035, MGC142011, MGC163260

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
adhesion G-protein coupled receptor G7
Names
G-protein coupled receptor 128

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308362.1NP_001295291.1  adhesion G-protein coupled receptor G7 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple alternate exons in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC069223, AK172769, AK295345, DA640995
    Consensus CDS
    CCDS77778.1
    UniProtKB/TrEMBL
    B7Z303, E9PHI0, Q6ZMH4
    Related
    ENSP00000419788.1, ENST00000475887.1
    Conserved Domains (2) summary
    pfam01825
    Location:88126
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:138419
    7tm_4; Olfactory receptor
  2. NM_032787.3NP_116176.2  adhesion G-protein coupled receptor G7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_116176.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC069223, AK027360, AK172769
    Consensus CDS
    CCDS2938.1
    UniProtKB/Swiss-Prot
    Q86SQ2, Q96K78
    UniProtKB/TrEMBL
    Q6ZMH4
    Related
    ENSP00000273352.3, ENST00000273352.8
    Conserved Domains (2) summary
    smart00303
    Location:383422
    GPS; G-protein-coupled receptor proteolytic site domain
    cd15257
    Location:431737
    7tmB2_GPR128; orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    100609601..100695479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449088.1XP_047305044.1  adhesion G-protein coupled receptor G7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    103315353..103401238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)