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PTPN5 protein tyrosine phosphatase, non-receptor type 5 [ Homo sapiens (human) ]

Gene ID: 84867, updated on 7-Oct-2018

Summary

Official Symbol
PTPN5provided by HGNC
Official Full Name
protein tyrosine phosphatase, non-receptor type 5provided by HGNC
Primary source
HGNC:HGNC:9657
See related
Ensembl:ENSG00000110786 MIM:176879; Vega:OTTHUMG00000134304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STEP; STEP61; PTPSTEP
Expression
Biased expression in brain (RPKM 11.0), testis (RPKM 0.9) and 1 other tissue See more
Orthologs

Genomic context

See PTPN5 in Genome Data Viewer
Location:
11p15.1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (18727928..18792721, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18749475..18814268, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376579 Neighboring gene transmembrane protein 86A Neighboring gene immunoglobulin superfamily member 22 Neighboring gene MAS related GPR family member X2 pseudogene Neighboring gene MAS related GPR family member X1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog

Pathways from BioSystems

  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14427

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphotyrosine residue binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 5
Names
neural-specific protein-tyrosine phosphatase
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
protein-tyrosine phosphatase striatum-enriched
striatal-enriched protein tyrosine phosphatase
striatum-enriched protein-tyrosine phosphatase
NP_001035059.1
NP_001265165.1
NP_001265167.1
NP_001265168.1
NP_008837.1
NP_116170.3
XP_011518713.1
XP_016873923.1
XP_016873924.1
XP_016873925.1
XP_016873926.1
XP_016873927.1
XP_016873928.1
XP_016873929.1
XP_016873930.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039970.1NP_001035059.1  tyrosine-protein phosphatase non-receptor type 5 isoform b

    See identical proteins and their annotated locations for NP_001035059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AK127312, AL832541, BC046435
    Consensus CDS
    CCDS41626.1
    UniProtKB/Swiss-Prot
    P54829
    UniProtKB/TrEMBL
    Q86TL3
    Conserved Domains (2) summary
    smart00194
    Location:267520
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:293520
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001278236.1NP_001265165.1  tyrosine-protein phosphatase non-receptor type 5 isoform b

    See identical proteins and their annotated locations for NP_001265165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. Variants 3 and 4 encode the same isoform b.
    Source sequence(s)
    AK127312, AL832541, BC046435
    Consensus CDS
    CCDS41626.1
    UniProtKB/Swiss-Prot
    P54829
    UniProtKB/TrEMBL
    Q86TL3
    Related
    ENSP00000379473.1, OTTHUMP00000165938, ENST00000396170.5, OTTHUMT00000259197
    Conserved Domains (2) summary
    smart00194
    Location:267520
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:293520
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_001278238.1NP_001265167.1  tyrosine-protein phosphatase non-receptor type 5 isoform c

    See identical proteins and their annotated locations for NP_001265167.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon in the 5' region which causes translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-teminus, compared to isoform a.
    Source sequence(s)
    AK127312, AK295604, AL832541, BC046435
    Consensus CDS
    CCDS60746.1
    UniProtKB/Swiss-Prot
    P54829
    UniProtKB/TrEMBL
    Q86TL3
    Related
    ENSP00000379471.1, OTTHUMP00000165960, ENST00000396168.1, OTTHUMT00000259230
    Conserved Domains (2) summary
    smart00194
    Location:275528
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:301528
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_001278239.1NP_001265168.1  tyrosine-protein phosphatase non-receptor type 5 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an internal exon in the 5' region which causes translation initiation at a downstream start codon, and also has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (d) has a shorter N-terminus and lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AK294673, AL832541, BC046435, BC064807
    UniProtKB/Swiss-Prot
    P54829
    UniProtKB/TrEMBL
    B7Z2F8, Q86TL3
    Conserved Domains (2) summary
    smart00194
    Location:243496
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:269496
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. NM_006906.1NP_008837.1  tyrosine-protein phosphatase non-receptor type 5 isoform a

    See identical proteins and their annotated locations for NP_008837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same longest isoform (a).
    Source sequence(s)
    AL832541, BC046435, BC064807
    Consensus CDS
    CCDS7845.1
    UniProtKB/Swiss-Prot
    P54829
    UniProtKB/TrEMBL
    Q86TL3
    Related
    ENSP00000351342.2, OTTHUMP00000165937, ENST00000358540.6, OTTHUMT00000259196
    Conserved Domains (1) summary
    smart00194
    Location:299552
    PTPc; Protein tyrosine phosphatase, catalytic domain
  6. NM_032781.3NP_116170.3  tyrosine-protein phosphatase non-receptor type 5 isoform a

    See identical proteins and their annotated locations for NP_116170.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform a.
    Source sequence(s)
    AK127312, BC046435, BC064807
    Consensus CDS
    CCDS7845.1
    UniProtKB/Swiss-Prot
    P54829
    UniProtKB/TrEMBL
    Q86TL3
    Conserved Domains (1) summary
    smart00194
    Location:299552
    PTPc; Protein tyrosine phosphatase, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    18727928..18792721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018439.1XP_016873928.1  tyrosine-protein phosphatase non-receptor type 5 isoform X5

  2. XM_017018436.1XP_016873925.1  tyrosine-protein phosphatase non-receptor type 5 isoform X2

  3. XM_017018437.1XP_016873926.1  tyrosine-protein phosphatase non-receptor type 5 isoform X3

  4. XM_017018435.2XP_016873924.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

  5. XM_017018434.2XP_016873923.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

  6. XM_017018440.2XP_016873929.1  tyrosine-protein phosphatase non-receptor type 5 isoform X7

  7. XM_011520411.3XP_011518713.1  tyrosine-protein phosphatase non-receptor type 5 isoform X6

    See identical proteins and their annotated locations for XP_011518713.1

    Conserved Domains (2) summary
    smart00194
    Location:299533
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:325533
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  8. XM_017018438.2XP_016873927.1  tyrosine-protein phosphatase non-receptor type 5 isoform X4

  9. XM_017018441.2XP_016873930.1  tyrosine-protein phosphatase non-receptor type 5 isoform X8

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