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RIOX2 ribosomal oxygenase 2 [ Homo sapiens (human) ]

Gene ID: 84864, updated on 13-Mar-2020

Summary

Official Symbol
RIOX2provided by HGNC
Official Full Name
ribosomal oxygenase 2provided by HGNC
Primary source
HGNC:HGNC:19441
See related
Ensembl:ENSG00000170854 MIM:612049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROX; MDIG; MINA; NO52; JMJD10; MINA53
Summary
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
Expression
Ubiquitous expression in thyroid (RPKM 23.6), skin (RPKM 10.0) and 24 other tissues See more
Orthologs

Genomic context

See RIOX2 in Genome Data Viewer
Location:
3q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (97941817..97972451, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (97660661..97691295, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 6 Neighboring gene uncharacterized LOC101929298 Neighboring gene uncharacterized LOC105373994 Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene) Neighboring gene Sharpr-MPRA regulatory region 13337

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14393, DKFZp762O1912

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone demethylase activity (H3-K36 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone demethylase activity (H3-K4 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
histone H3-K36 demethylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-K4 demethylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribosomal oxygenase 2
Names
60S ribosomal protein L27a histidine hydroxylase
MYC induced nuclear antigen
bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
histone lysine demethylase MINA
mineral dust induced gene protein
myc-induced nuclear antigen, 53 kDa
nucleolar protein 52
ribosomal oxygenase MINA
NP_001035998.1
NP_001248758.1
NP_116167.3
NP_694822.2
XP_005247895.1
XP_011511546.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042533.2NP_001035998.1  ribosomal oxygenase 2 isoform a

    See identical proteins and their annotated locations for NP_001035998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Variants 1 and 2 encode the same protein (isoform A).
    Source sequence(s)
    AC110491, AL550737, AY302110, DA310030
    Consensus CDS
    CCDS43114.1
    UniProtKB/Swiss-Prot
    Q8IUF8
    Related
    ENSP00000328251.6, ENST00000333396.11
    Conserved Domains (1) summary
    pfam08007
    Location:52364
    Cupin_4; Cupin superfamily protein
  2. NM_001261829.1NP_001248758.1  ribosomal oxygenase 2 isoform b

    See identical proteins and their annotated locations for NP_001248758.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate splice sites in the 5' UTR and 3' coding region, compared to variant 1, and encodes a shorter protein (isoform B), compared to isoform A. Variants 3 and 4 encode the same protein (isoform B).
    Source sequence(s)
    AC026100, AC110491, AK027299, DA310030
    Consensus CDS
    CCDS2929.1
    UniProtKB/Swiss-Prot
    Q8IUF8
    Conserved Domains (1) summary
    pfam08007
    Location:52363
    Cupin_4; Cupin superfamily protein
  3. NM_032778.5NP_116167.3  ribosomal oxygenase 2 isoform b

    See identical proteins and their annotated locations for NP_116167.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform B), compared to isoform A. Variants 3 and 4 encode the same protein (isoform B).
    Source sequence(s)
    AB083190, AC026100, AC110491, AL550737, DA310030
    Consensus CDS
    CCDS2929.1
    UniProtKB/Swiss-Prot
    Q8IUF8
    Related
    ENSP00000353395.4, ENST00000360258.8
    Conserved Domains (1) summary
    pfam08007
    Location:52363
    Cupin_4; Cupin superfamily protein
  4. NM_153182.4NP_694822.2  ribosomal oxygenase 2 isoform a

    See identical proteins and their annotated locations for NP_694822.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1, and encodes isoform A. Variants 1 and 2 encode the same protein (isoform A).
    Source sequence(s)
    AC110491, DA310030, DQ453796
    Consensus CDS
    CCDS43114.1
    UniProtKB/Swiss-Prot
    Q8IUF8
    Related
    ENSP00000377748.2, ENST00000394198.7
    Conserved Domains (1) summary
    pfam08007
    Location:52364
    Cupin_4; Cupin superfamily protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    97941817..97972451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247838.4XP_005247895.1  ribosomal oxygenase 2 isoform X1

    See identical proteins and their annotated locations for XP_005247895.1

    UniProtKB/Swiss-Prot
    Q8IUF8
    Conserved Domains (1) summary
    pfam08007
    Location:52364
    Cupin_4; Cupin superfamily protein
  2. XM_011513244.3XP_011511546.1  ribosomal oxygenase 2 isoform X2

    Conserved Domains (1) summary
    cl21464
    Location:7133
    cupin_like; Conserved domain found in cupin and related proteins

RNA

  1. XR_001740332.2 RNA Sequence

  2. XR_241516.5 RNA Sequence

  3. XR_001740331.2 RNA Sequence

    Related
    ENST00000514314.5
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