Format

Send to:

Choose Destination

ZNF503 zinc finger protein 503 [ Homo sapiens (human) ]

Gene ID: 84858, updated on 13-Mar-2020

Summary

Official Symbol
ZNF503provided by HGNC
Official Full Name
zinc finger protein 503provided by HGNC
Primary source
HGNC:HGNC:23589
See related
Ensembl:ENSG00000165655 MIM:613902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nlz2; NOLZ1; NOLZ-1
Expression
Broad expression in kidney (RPKM 5.4), prostate (RPKM 1.9) and 14 other tissues See more
Orthologs

Genomic context

See ZNF503 in Genome Data Viewer
Location:
10q22.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (75279726..75401894, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (77157602..77161513, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 25 Neighboring gene high mobility group AT-hook 1 pseudogene 5 Neighboring gene ZNF503 antisense RNA 1 Neighboring gene sperm autoantigenic protein 17 pseudogene 1 Neighboring gene VISTA enhancer hs484 Neighboring gene ZNF503 antisense RNA 2 Neighboring gene uncharacterized LOC101929234

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC2555, FLJ45745

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
repressing transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G1 to G0 transition involved in cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032772.6NP_116161.2  zinc finger protein 503

    See identical proteins and their annotated locations for NP_116161.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AC010997, AI701640, BC011625, BQ574961
    Consensus CDS
    CCDS7350.1
    UniProtKB/Swiss-Prot
    Q96F45
    Related
    ENSP00000361602.4, ENST00000372524.5
    Conserved Domains (2) summary
    sd00017
    Location:516542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12402
    Location:355415
    nlz1; NocA-like zinc-finger protein 1

RNA

  1. NR_120651.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains three alternate 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010997, AI522172, BX105802

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    75279726..75401894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center