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TRIM52 tripartite motif containing 52 [ Homo sapiens (human) ]

Gene ID: 84851, updated on 4-Nov-2022

Summary

Official Symbol
TRIM52provided by HGNC
Official Full Name
tripartite motif containing 52provided by HGNC
Primary source
HGNC:HGNC:19024
See related
Ensembl:ENSG00000183718 MIM:619265; AllianceGenome:HGNC:19024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF102
Summary
Enables transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and protein autoubiquitination. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 9.5), spleen (RPKM 9.1) and 25 other tissues See more
Orthologs
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Genomic context

See TRIM52 in Genome Data Viewer
Location:
5q35.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (181249062..181261143, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181815100..181821096, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180682147..180688144, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene receptor for activated C kinase 1 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene uncharacterized LOC101928649 Neighboring gene small nucleolar RNA, C/D box 95 Neighboring gene TRIM52 antisense RNA 1 (head to head) Neighboring gene RNA, U6 small nuclear 705, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC16175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM52
Names
RING finger protein 102
tripartite motif-containing protein 52
NP_001332977.1
NP_001332978.1
NP_001332979.1
NP_001332980.1
NP_116154.1
XP_016865480.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346048.2NP_001332977.1  E3 ubiquitin-protein ligase TRIM52 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008443, KF510262
    Consensus CDS
    CCDS93844.1
    UniProtKB/TrEMBL
    A0A8I5KQM7
    Related
    ENSP00000508553.1, ENST00000688015.1
    Conserved Domains (2) summary
    cd16602
    Location:1648
    RING-HC_TRIM41_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM41, TRIM52 and similar proteins
    cd19762
    Location:225268
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
  2. NM_001346049.2NP_001332978.1  E3 ubiquitin-protein ligase TRIM52 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008443, KF510262
    Consensus CDS
    CCDS93843.1
    UniProtKB/TrEMBL
    A0A8I5KYD8
    Related
    ENSP00000509812.1, ENST00000685507.1
  3. NM_001346050.2NP_001332979.1  E3 ubiquitin-protein ligase TRIM52 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008443, KF510262
    Consensus CDS
    CCDS93846.1
    UniProtKB/TrEMBL
    A0A8I5KW90
    Related
    ENSP00000510569.1, ENST00000686030.1
  4. NM_001346051.2NP_001332980.1  E3 ubiquitin-protein ligase TRIM52 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008443, KF510262
    Consensus CDS
    CCDS93845.1
    UniProtKB/TrEMBL
    A0A8I5KRY2
    Related
    ENSP00000509327.1, ENST00000510796.2
  5. NM_032765.4NP_116154.1  E3 ubiquitin-protein ligase TRIM52 isoform 1

    See identical proteins and their annotated locations for NP_116154.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA806088, AC008443, AK026706, BC007372
    Consensus CDS
    CCDS4467.1
    UniProtKB/Swiss-Prot
    Q59G66, Q96A61
    UniProtKB/TrEMBL
    L0CQ38
    Related
    ENSP00000483005.1, ENST00000611618.1
    Conserved Domains (2) summary
    cd00021
    Location:226263
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd16602
    Location:1648
    RING-HC_TRIM41_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM41, TRIM52 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    181249062..181261143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009991.3XP_016865480.1  E3 ubiquitin-protein ligase TRIM52 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KXQ2
    Related
    ENSP00000509065.1, ENST00000503005.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    181815100..181821096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)