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GALR3 galanin receptor 3 [ Homo sapiens (human) ]

Gene ID: 8484, updated on 1-Jun-2020

Summary

Official Symbol
GALR3provided by HGNC
Official Full Name
galanin receptor 3provided by HGNC
Primary source
HGNC:HGNC:4134
See related
Ensembl:ENSG00000128310 MIM:603692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See GALR3 in Genome Data Viewer
Location:
22q13.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (37823382..37825485)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38219389..38221502)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H1.0 linker histone Neighboring gene glycine C-acetyltransferase Neighboring gene ankyrin repeat domain 54 Neighboring gene microRNA 658 Neighboring gene microRNA 659

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galanin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galanin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
9+0 non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
galanin receptor type 3
Names
GAL3-R
GALR-3
galanin receptor, family member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003614.2NP_003605.1  galanin receptor type 3

    See identical proteins and their annotated locations for NP_003605.1

    Status: REVIEWED

    Source sequence(s)
    AF073799
    Consensus CDS
    CCDS13958.1
    UniProtKB/Swiss-Prot
    O60755
    Related
    ENSP00000249041.2, ENST00000249041.3
    Conserved Domains (2) summary
    pfam00001
    Location:34291
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:24162
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    37823382..37825485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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