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ZNF496 zinc finger protein 496 [ Homo sapiens (human) ]

Gene ID: 84838, updated on 21-Dec-2019

Summary

Official Symbol
ZNF496provided by HGNC
Official Full Name
zinc finger protein 496provided by HGNC
Primary source
HGNC:HGNC:23713
See related
Ensembl:ENSG00000162714 MIM:613911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIZP1; ZFP496; ZSCAN49; ZKSCAN17
Expression
Ubiquitous expression in testis (RPKM 3.4), ovary (RPKM 3.0) and 25 other tissues See more
Orthologs

Genomic context

See ZNF496 in Genome Data Viewer
Location:
1q44
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (247297415..247331867, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247460717..247495294, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373273 Neighboring gene vomeronasal 1 receptor 5 (gene/pseudogene) Neighboring gene translation initiation factor IF-2-like Neighboring gene Sharpr-MPRA regulatory region 5917 Neighboring gene uncharacterized LOC107985375 Neighboring gene NLR family pyrin domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15548

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger protein 496
Names
NSD1 (nuclear receptor binding SET-domain containing 1)-interacting zinc finger protein 1
zinc finger protein with KRAB and SCAN domains 17

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329733.2NP_001316662.1  zinc finger protein 496 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC104335
    Conserved Domains (2) summary
    cd07765
    Location:222259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    pfam02023
    Location:50126
    SCAN; SCAN domain
  2. NM_032752.3NP_116141.1  zinc finger protein 496 isoform 1

    See identical proteins and their annotated locations for NP_116141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC104335, BC007263, BC025794, BU740940, HY023128
    Consensus CDS
    CCDS1631.1
    UniProtKB/Swiss-Prot
    Q96IT1
    UniProtKB/TrEMBL
    A0A024R5Q5
    Related
    ENSP00000294753.4, ENST00000294753.8
    Conserved Domains (6) summary
    cd07765
    Location:222259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:223275
    KRAB; krueppel associated box
    COG5048
    Location:427586
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:408428
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:463485
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:50126
    SCAN; SCAN domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    247297415..247331867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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