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ABHD14B abhydrolase domain containing 14B [ Homo sapiens (human) ]

Gene ID: 84836, updated on 1-Jun-2020

Summary

Official Symbol
ABHD14Bprovided by HGNC
Official Full Name
abhydrolase domain containing 14Bprovided by HGNC
Primary source
HGNC:HGNC:28235
See related
Ensembl:ENSG00000114779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIB; HEL-S-299
Expression
Ubiquitous expression in fat (RPKM 33.8), kidney (RPKM 32.8) and 25 other tissues See more
Orthologs

Genomic context

See ABHD14B in Genome Data Viewer
Location:
3p21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (51968510..51974630, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52002526..52008646, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 3 Neighboring gene G protein-coupled receptor 62 Neighboring gene poly(rC) binding protein 4 Neighboring gene ABHD14A-ACY1 readthrough Neighboring gene abhydrolase domain containing 14A Neighboring gene aminoacylase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15429

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein ABHD14B
Names
CCG1-interacting factor B
abhydrolase domain-containing protein 14B
alpha/beta hydrolase domain-containing protein 14B
cell cycle gene 1-interacting factor B
epididymis secretory protein Li 299
epididymis secretory sperm binding protein
NP_001139786.1
NP_001241682.1
NP_116139.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146314.1NP_001139786.1  protein ABHD14B isoform 1

    See identical proteins and their annotated locations for NP_001139786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK096073, BC056411, BU732936
    Consensus CDS
    CCDS2842.1
    UniProtKB/Swiss-Prot
    Q96IU4
    UniProtKB/TrEMBL
    V9HW87
    Related
    ENSP00000354841.5, ENST00000361143.9
    Conserved Domains (2) summary
    COG0596
    Location:8136
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl26327
    Location:104206
    Abhydrolase_1; alpha/beta hydrolase fold
  2. NM_001254753.1NP_001241682.1  protein ABHD14B isoform 3

    See identical proteins and their annotated locations for NP_001241682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, which includes the translational start codon, compared to variant 1. The encoded protein is shorter and has a distinct N-terminus.
    Source sequence(s)
    AK096073, BU732936
    UniProtKB/Swiss-Prot
    Q96IU4
    Related
    ENST00000487005.1
    Conserved Domains (2) summary
    COG0596
    Location:102171
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:53150
    Abhydrolase_5; Alpha/beta hydrolase family
  3. NM_032750.2NP_116139.1  protein ABHD14B isoform 1

    See identical proteins and their annotated locations for NP_116139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK096073, BC007234, BU732936
    Consensus CDS
    CCDS2842.1
    UniProtKB/Swiss-Prot
    Q96IU4
    UniProtKB/TrEMBL
    V9HW87
    Related
    ENSP00000378455.2, ENST00000395008.6
    Conserved Domains (2) summary
    COG0596
    Location:8136
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl26327
    Location:104206
    Abhydrolase_1; alpha/beta hydrolase fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    51968510..51974630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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