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ADTRP androgen dependent TFPI regulating protein [ Homo sapiens (human) ]

Gene ID: 84830, updated on 22-Sep-2022

Summary

Official Symbol
ADTRPprovided by HGNC
Official Full Name
androgen dependent TFPI regulating proteinprovided by HGNC
Primary source
HGNC:HGNC:21214
See related
Ensembl:ENSG00000111863 MIM:614348; AllianceGenome:HGNC:21214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIG1L; C6orf105; dJ413H6.1
Summary
Enables hydrolase activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; negative regulation of secretion by cell; and positive regulation of macromolecule metabolic process. Located in caveola and cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine (RPKM 12.0), duodenum (RPKM 8.7) and 8 other tissues See more
Orthologs
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Genomic context

See ADTRP in Genome Data Viewer
Location:
6p24.1
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (11713523..11778803, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (11581768..11647014, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (11713756..11779036, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 170B Neighboring gene uncharacterized LOC340184 Neighboring gene small nucleolar RNA SNORA67 Neighboring gene uncharacterized LOC124901258 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr6:11770721-11771242 and GRCh37_chr6:11771243-11771766 Neighboring gene uncharacterized LOC107986567 Neighboring gene uncharacterized LOC124901257 Neighboring gene uncharacterized LOC102724379 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
androgen-dependent TFPI-regulating protein
Names
FAHFA hydrolase ADTRP
androgen-dependent TPF1-regulating protein
fatty acid esters of hydroxy fatty acids hydrolase ADTRP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143948.2NP_001137420.1  androgen-dependent TFPI-regulating protein isoform 1

    See identical proteins and their annotated locations for NP_001137420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI147084, AI336841, AJ420520, AK300919, AL022724
    Consensus CDS
    CCDS47374.1
    UniProtKB/Swiss-Prot
    Q96IZ2
    Related
    ENSP00000229583.5, ENST00000229583.9
    Conserved Domains (1) summary
    pfam04750
    Location:5234
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  2. NM_032744.4NP_116133.1  androgen-dependent TFPI-regulating protein isoform 2

    See identical proteins and their annotated locations for NP_116133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI147084, AI336841, AJ420520, AL022724, BC007011
    Consensus CDS
    CCDS4521.1
    UniProtKB/Swiss-Prot
    Q5THW1, Q96IZ2
    Related
    ENSP00000404416.2, ENST00000414691.8
    Conserved Domains (1) summary
    pfam04750
    Location:5216
    Far-17a_AIG1; FAR-17a/AIG1-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    11713523..11778803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514956.2XP_011513258.1  androgen-dependent TFPI-regulating protein isoform X1

    See identical proteins and their annotated locations for XP_011513258.1

    UniProtKB/Swiss-Prot
    Q96IZ2
    Conserved Domains (1) summary
    pfam04750
    Location:5216
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  2. XM_047419420.1XP_047275376.1  androgen-dependent TFPI-regulating protein isoform X6

  3. XM_047419418.1XP_047275374.1  androgen-dependent TFPI-regulating protein isoform X2

  4. XM_011514958.3XP_011513260.1  androgen-dependent TFPI-regulating protein isoform X3

    Conserved Domains (1) summary
    pfam04750
    Location:5169
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  5. XM_011514959.2XP_011513261.1  androgen-dependent TFPI-regulating protein isoform X4

    Related
    ENSP00000368726.2, ENST00000379415.6
    Conserved Domains (1) summary
    pfam04750
    Location:5169
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  6. XM_047419419.1XP_047275375.1  androgen-dependent TFPI-regulating protein isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    11581768..11647014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)