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ADTRP androgen dependent TFPI regulating protein [ Homo sapiens (human) ]

Gene ID: 84830, updated on 22-Aug-2020

Summary

Official Symbol
ADTRPprovided by HGNC
Official Full Name
androgen dependent TFPI regulating proteinprovided by HGNC
Primary source
HGNC:HGNC:21214
See related
Ensembl:ENSG00000111863 MIM:614348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIG1L; C6orf105; dJ413H6.1
Expression
Biased expression in small intestine (RPKM 12.0), duodenum (RPKM 8.7) and 8 other tissues See more
Orthologs

Genomic context

See ADTRP in Genome Data Viewer
Location:
6p24.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (11713523..11779628, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (11711505..11779861, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 170B Neighboring gene uncharacterized LOC340184 Neighboring gene uncharacterized LOC107986566 Neighboring gene uncharacterized LOC107986569 Neighboring gene uncharacterized LOC107986567 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
androgen-dependent TFPI-regulating protein
Names
FAHFA hydrolase ADTRP
androgen-dependent TPF1-regulating protein
fatty acid esters of hydroxy fatty acids hydrolase ADTRP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143948.2NP_001137420.1  androgen-dependent TFPI-regulating protein isoform 1

    See identical proteins and their annotated locations for NP_001137420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI147084, AI336841, AJ420520, AK300919, AL022724
    Consensus CDS
    CCDS47374.1
    UniProtKB/Swiss-Prot
    Q96IZ2
    Related
    ENSP00000229583.5, ENST00000229583.9
    Conserved Domains (1) summary
    pfam04750
    Location:5234
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  2. NM_032744.4NP_116133.1  androgen-dependent TFPI-regulating protein isoform 2

    See identical proteins and their annotated locations for NP_116133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI147084, AI336841, AJ420520, AL022724, BC007011
    Consensus CDS
    CCDS4521.1
    UniProtKB/Swiss-Prot
    Q96IZ2
    Related
    ENSP00000404416.2, ENST00000414691.7
    Conserved Domains (1) summary
    pfam04750
    Location:5216
    Far-17a_AIG1; FAR-17a/AIG1-like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    11713523..11779628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249454.3XP_005249511.1  androgen-dependent TFPI-regulating protein isoform X2

    See identical proteins and their annotated locations for XP_005249511.1

    UniProtKB/Swiss-Prot
    Q96IZ2
    Conserved Domains (1) summary
    pfam04750
    Location:5216
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  2. XM_011514956.1XP_011513258.1  androgen-dependent TFPI-regulating protein isoform X1

    See identical proteins and their annotated locations for XP_011513258.1

    UniProtKB/Swiss-Prot
    Q96IZ2
    Conserved Domains (1) summary
    pfam04750
    Location:5216
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  3. XM_017011377.1XP_016866866.1  androgen-dependent TFPI-regulating protein isoform X5

  4. XM_011514958.2XP_011513260.1  androgen-dependent TFPI-regulating protein isoform X3

    Conserved Domains (1) summary
    pfam04750
    Location:5169
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  5. XM_011514959.1XP_011513261.1  androgen-dependent TFPI-regulating protein isoform X4

    Related
    ENSP00000422927.1, ENST00000506810.1
    Conserved Domains (1) summary
    pfam04750
    Location:5169
    Far-17a_AIG1; FAR-17a/AIG1-like protein

RNA

  1. XR_926322.2 RNA Sequence

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