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FCRLA Fc receptor like A [ Homo sapiens (human) ]

Gene ID: 84824, updated on 22-Aug-2020

Summary

Official Symbol
FCRLAprovided by HGNC
Official Full Name
Fc receptor like Aprovided by HGNC
Primary source
HGNC:HGNC:18504
See related
Ensembl:ENSG00000132185 MIM:606891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2
Summary
This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Expression
Biased expression in lymph node (RPKM 32.1), spleen (RPKM 21.2) and 3 other tissues See more
Orthologs

Genomic context

See FCRLA in Genome Data Viewer
Location:
1q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161707022..161714352)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161676762..161684142)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Fc fragment of IgG receptor IIb Neighboring gene ribosomal protein L31 pseudogene 11 Neighboring gene Fc receptor like B Neighboring gene RNA, 7SL, cytoplasmic 466, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4595

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Fc receptor-like A
Names
Fc receptor homolog expressed in B cells (FREB)
Fc receptor related protein X
Fc receptor-like and mucin-like 1
fc receptor homolog expressed in B-cells
fc receptor-like and mucin-like protein 1
fc receptor-like protein
fc receptor-related protein X

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184866.2NP_001171795.2  Fc receptor-like A isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1). This variant has also been called FCRLa1.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53415.1
    Related
    ENSP00000356930.3, ENST00000367953.7
    Conserved Domains (2) summary
    pfam13895
    Location:177266
    Ig_2; Immunoglobulin domain
    cl11960
    Location:85152
    Ig; Immunoglobulin domain
  2. NM_001184867.2NP_001171796.2  Fc receptor-like A isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. This variant has also been called FCRLb.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53417.1
    Related
    ENSP00000439838.1, ENST00000546024.5
    Conserved Domains (1) summary
    pfam13895
    Location:82171
    Ig_2; Immunoglobulin domain
  3. NM_001184870.2NP_001171799.2  Fc receptor-like A isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. This variant has also been called FCRLc1.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53416.1
    Related
    ENSP00000442870.1, ENST00000540521.5
    Conserved Domains (1) summary
    pfam13895
    Location:37126
    Ig_2; Immunoglobulin domain
  4. NM_001184871.2NP_001171800.2  Fc receptor-like A isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks four alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 7) is shorter when it is compared to isoform 1. This variant has also been called FCRLe.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53420.1
    Related
    ENSP00000344808.3, ENST00000350710.3
  5. NM_001184872.2NP_001171801.2  Fc receptor-like A isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1. This variant has also been called FCRLc2.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53419.1
    Related
    ENSP00000356934.2, ENST00000367957.6
    Conserved Domains (1) summary
    pfam13895
    Location:31120
    Ig_2; Immunoglobulin domain
  6. NM_001184873.2NP_001171802.2  Fc receptor-like A isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 6) is shorter when it is compared to isoform 1. This variant has also been called FCRLd.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53418.1
    Related
    ENSP00000356926.2, ENST00000367949.6
  7. NM_001366195.2NP_001353124.2  Fc receptor-like A isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AL359541
    Conserved Domains (2) summary
    pfam13895
    Location:176265
    Ig_2; Immunoglobulin domain
    cl11960
    Location:84151
    Ig; Immunoglobulin domain
  8. NM_001366196.2NP_001353125.2  Fc receptor-like A isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AL359541
    Related
    ENSP00000294798.7, ENST00000349527.8
    Conserved Domains (1) summary
    cl11960
    Location:79146
    Ig; Immunoglobulin domain
  9. NM_032738.4NP_116127.4  Fc receptor-like A isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame segment, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. This variant has also been called FCRLa.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS30926.1
    Related
    ENSP00000236938.6, ENST00000236938.10
    Conserved Domains (2) summary
    pfam13895
    Location:171260
    Ig_2; Immunoglobulin domain
    cl11960
    Location:79146
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161707022..161714352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711581.3XP_006711644.1  Fc receptor-like A isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:112185
    IG_like; Immunoglobulin like
    pfam13895
    Location:106194
    Ig_2; Immunoglobulin domain
  2. XM_011510065.1XP_011508367.1  Fc receptor-like A isoform X3

    Conserved Domains (2) summary
    smart00410
    Location:112166
    IG_like; Immunoglobulin like
    cl11960
    Location:102188
    Ig; Immunoglobulin domain
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