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IL17RC interleukin 17 receptor C [ Homo sapiens (human) ]

Gene ID: 84818, updated on 1-Jun-2020

Summary

Official Symbol
IL17RCprovided by HGNC
Official Full Name
interleukin 17 receptor Cprovided by HGNC
Primary source
HGNC:HGNC:18358
See related
Ensembl:ENSG00000163702 MIM:610925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CANDF9; IL17RL; IL17-RL
Summary
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in prostate (RPKM 15.4), skin (RPKM 9.6) and 25 other tissues See more
Orthologs

Genomic context

See IL17RC in Genome Data Viewer
Location:
3p25.3; 3p25.3-p24.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9917074..9933627)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9958758..9975305)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14744 Neighboring gene interleukin 17 receptor E Neighboring gene RNA, U6 small nuclear 882, pseudogene Neighboring gene cysteine rich with EGF like domains 1 Neighboring gene PRRT3 antisense RNA 1 Neighboring gene 3p25 PRRT3 Alu-mediated recombination region Neighboring gene proline rich transmembrane protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ95963, FLJ96005, MGC10763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-17 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
granulocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
interleukin-17-mediated signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-17 receptor C
Names
IL-17 receptor C
IL-17RL
IL17F receptor
IL17Rhom
interleukin-17 receptor homolog
interleukin-17 receptor-like protein
zcytoR14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029376.2 RefSeqGene

    Range
    5001..21524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1311

mRNA and Protein(s)

  1. NM_001203263.2NP_001190192.2  interleukin-17 receptor C isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the penultimate coding exon compared to variant 1, however, maintains the reading frame. This results in a shorter isoform (4) missing a protein segment in the C-terminal region compared to isoform 1.
    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS56240.1
    Related
    ENSP00000396064.1, ENST00000413608.2
  2. NM_001203264.1NP_001190193.1  interleukin-17 receptor C isoform 5 precursor

    See identical proteins and their annotated locations for NP_001190193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks 2 in-frame coding exons (exon 12 and penultimate exon) compared to variant 1, resulting in a shorter isoform (5, also known as IL-17RCdelta12) missing 2 internal protein segments compared to isoform 1. It has been reported that isoforms lacking exon 12 lose the ability to bind cytokines, IL-17A and IL-17F (PMID:17911633).
    Source sequence(s)
    AK096824, AK225650, AY358840, DC381087, DC386743
    Consensus CDS
    CCDS74898.1
    UniProtKB/Swiss-Prot
    Q8NAC3
    Related
    ENSP00000395315.3, ENST00000416074.6
    Conserved Domains (2) summary
    pfam08357
    Location:489636
    SEFIR; SEFIR domain
    pfam15037
    Location:71442
    IL17_R_N; Interleukin-17 receptor extracellular region
  3. NM_001203265.2NP_001190194.2  interleukin-17 receptor C isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks 2 in-frame coding exons (exons 7 and 12) compared to variant 1, resulting in a shorter isoform (6, also known as IL-17RCdelta7,12) missing 2 internal protein segments compared to isoform 1. It has been reported that isoforms lacking exon 12 lose the ability to bind cytokines, IL-17A and IL-17F (PMID:17911633).
    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS56241.1
    Related
    ENSP00000407894.1, ENST00000455057.5
  4. NM_001367278.1NP_001354207.1  interleukin-17 receptor C isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC018809
    Conserved Domains (2) summary
    pfam08357
    Location:493640
    SEFIR; SEFIR domain
    pfam15037
    Location:71446
    IL17_R_N; Interleukin-17 receptor extracellular region
  5. NM_001367279.1NP_001354208.1  interleukin-17 receptor C isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC018809
    Conserved Domains (2) summary
    pfam08357
    Location:466613
    SEFIR; SEFIR domain
    pfam15037
    Location:71419
    IL17_R_N; Interleukin-17 receptor extracellular region
  6. NM_001367280.1NP_001354209.1  interleukin-17 receptor C isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC018809
    Related
    ENST00000483582.5
    Conserved Domains (2) summary
    pfam08357
    Location:491638
    SEFIR; SEFIR domain
    pfam15037
    Location:71444
    IL17_R_N; Interleukin-17 receptor extracellular region
  7. NM_032732.6NP_116121.3  interleukin-17 receptor C isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon (exon 7) compared to variant 1, resulting in a shorter isoform (3, also known as IL-17RCdelta7) missing an internal protein segment compared to isoform 1. It has been reported that isoform lacking exon 7 retains the ability to bind cytokines, IL-17A and IL-17F (PMID:17911633).
    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS2591.2
    Related
    ENSP00000373323.4, ENST00000383812.9
  8. NM_153460.4NP_703190.2  interleukin-17 receptor C isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript containing all the coding exons, and encodes isoform 1 (also known as IL-17RCFL).
    Source sequence(s)
    AC018809, AF458065, AK096824, AK225650, AY358840, DC381087
    Consensus CDS
    CCDS46746.1
    Related
    ENSP00000384969.3, ENST00000403601.8
    Conserved Domains (2) summary
    pfam08357
    Location:519666
    SEFIR; SEFIR domain
    pfam15037
    Location:71459
    IL17_R_N; Interleukin-17 receptor extracellular region
  9. NM_153461.4NP_703191.2  interleukin-17 receptor C isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal coding exon compared to variant 1, resulting in a longer isoform (2) containing an additional protein segment compared to isoform 1.
    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS2590.1
    Related
    ENSP00000295981.3, ENST00000295981.7

RNA

  1. NR_037807.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks exon 7 and is alternatively spliced in the mid-coding region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC018809
    Related
    ENST00000466046.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    9917074..9933627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007327.1XP_016862816.1  interleukin-17 receptor C isoform X2

  2. XM_017007329.1XP_016862818.1  interleukin-17 receptor C isoform X4

  3. XM_017007336.1XP_016862825.1  interleukin-17 receptor C isoform X12

  4. XM_024453793.1XP_024309561.1  interleukin-17 receptor C isoform X10

    Conserved Domains (2) summary
    pfam08357
    Location:562709
    SEFIR; SEFIR domain
    pfam15037
    Location:142515
    IL17_R_N; Interleukin-17 receptor extracellular region
  5. XM_017007339.1XP_016862828.1  interleukin-17 receptor C isoform X15

  6. XM_017007338.1XP_016862827.1  interleukin-17 receptor C isoform X14

  7. XM_017007326.1XP_016862815.1  interleukin-17 receptor C isoform X1

  8. XM_017007333.1XP_016862822.1  interleukin-17 receptor C isoform X8

  9. XM_017007328.1XP_016862817.1  interleukin-17 receptor C isoform X3

  10. XM_017007330.1XP_016862819.1  interleukin-17 receptor C isoform X5

  11. XM_017007331.1XP_016862820.1  interleukin-17 receptor C isoform X6

  12. XM_017007332.1XP_016862821.1  interleukin-17 receptor C isoform X7

  13. XM_017007335.1XP_016862824.1  interleukin-17 receptor C isoform X11

  14. XM_024453794.1XP_024309562.1  interleukin-17 receptor C isoform X16

    Conserved Domains (2) summary
    pfam08357
    Location:545692
    SEFIR; SEFIR domain
    pfam15037
    Location:142485
    IL17_R_N; Interleukin-17 receptor extracellular region
  15. XM_017007334.1XP_016862823.1  interleukin-17 receptor C isoform X9

  16. XM_017007337.1XP_016862826.1  interleukin-17 receptor C isoform X13

  17. XM_017007340.2XP_016862829.1  interleukin-17 receptor C isoform X17

  18. XM_017007341.2XP_016862830.1  interleukin-17 receptor C isoform X18

  19. XM_017007345.2XP_016862834.1  interleukin-17 receptor C isoform X22

  20. XM_017007348.2XP_016862837.1  interleukin-17 receptor C isoform X25

  21. XM_017007342.1XP_016862831.1  interleukin-17 receptor C isoform X19

  22. XM_017007343.1XP_016862832.1  interleukin-17 receptor C isoform X20

  23. XM_017007347.1XP_016862836.1  interleukin-17 receptor C isoform X24

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153462.1: Suppressed sequence

    Description
    NM_153462.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_153463.1: Suppressed sequence

    Description
    NM_153463.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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