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PLPP7 phospholipid phosphatase 7 (inactive) [ Homo sapiens (human) ]

Gene ID: 84814, updated on 4-Nov-2022

Summary

Official Symbol
PLPP7provided by HGNC
Official Full Name
phospholipid phosphatase 7 (inactive)provided by HGNC
Primary source
HGNC:HGNC:28174
See related
Ensembl:ENSG00000160539 MIM:618743; AllianceGenome:HGNC:28174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET39; C9orf67; PPAPDC3
Summary
Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to act upstream of or within negative regulation of myotube differentiation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in membrane and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart (RPKM 14.9), brain (RPKM 2.9) and 9 other tissues See more
Orthologs
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Genomic context

See PLPP7 in Genome Data Viewer
Location:
9q34.13
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (131289723..131309261)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143498005..143517537)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (134165110..134184648)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1963 Neighboring gene family with sequence similarity 78 member A Neighboring gene Sharpr-MPRA regulatory region 12946 Neighboring gene uncharacterized LOC105376299 Neighboring gene uncharacterized LOC105376300 Neighboring gene proline rich coiled-coil 2B Neighboring gene Sharpr-MPRA regulatory region 9532

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14662, KIAA0515, MGC12921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sphingosine-1-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
inactive phospholipid phosphatase 7
Names
epididymis secretory sperm binding protein
nuclear envelope transmembrane protein NET39
phosphatidic acid phosphatase type 2 domain containing 3
phosphatidic acid phosphatase type 2 domain-containing protein 3
probable lipid phosphate phosphatase PPAPDC3
NP_116117.3
XP_005272287.1
XP_005272288.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411021.1NP_001397950.1  inactive phospholipid phosphatase 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL354855
    Consensus CDS
    CCDS94515.1
    UniProtKB/TrEMBL
    X6R886
  2. NM_032728.4NP_116117.3  inactive phospholipid phosphatase 7 isoform 1

    See identical proteins and their annotated locations for NP_116117.3

    Status: VALIDATED

    Source sequence(s)
    AK075207, AL354855, BC006362
    Consensus CDS
    CCDS6942.1
    UniProtKB/Swiss-Prot
    Q8NBV4, Q9BRC3
    UniProtKB/TrEMBL
    A0A384NPM3
    Related
    ENSP00000361338.3, ENST00000372264.4
    Conserved Domains (1) summary
    cd03391
    Location:97255
    PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    131289723..131309261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272230.5XP_005272287.1  inactive phospholipid phosphatase 7 isoform X1

    Conserved Domains (1) summary
    cl00474
    Location:97152
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
  2. XM_005272231.3XP_005272288.1  inactive phospholipid phosphatase 7 isoform X2

    UniProtKB/TrEMBL
    X6R886
    Related
    ENSP00000361335.1, ENST00000372261.1
    Conserved Domains (1) summary
    cl00474
    Location:97150
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    143498005..143517537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)