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GPAT3 glycerol-3-phosphate acyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 84803, updated on 1-Jun-2020

Summary

Official Symbol
GPAT3provided by HGNC
Official Full Name
glycerol-3-phosphate acyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:28157
See related
Ensembl:ENSG00000138678 MIM:610958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAG1; AGPAT8; AGPAT9; AGPAT10; AGPAT 10; HMFN0839; LPAAT-theta
Summary
This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Expression
Broad expression in kidney (RPKM 23.1), duodenum (RPKM 10.2) and 14 other tissues See more
Orthologs

Genomic context

See GPAT3 in Genome Data Viewer
Location:
4q21.23
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (83535634..83605875)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (84456886..84527028)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene abraxas 1, BRCA1 A complex subunit Neighboring gene solute carrier family 25 member 14 pseudogene 1 Neighboring gene ribosomal protein L30 pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 4722 Neighboring gene Sharpr-MPRA regulatory region 10444 Neighboring gene Sharpr-MPRA regulatory region 4612

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11324

Gene Ontology Provided by GOA

Process Evidence Code Pubs
CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
regulation of TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glycerol-3-phosphate acyltransferase 3
Names
1-AGP acyltransferase 9
1-AGPAT 9
1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10
1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9
1-acylglycerol-3-phosphate O-acyltransferase 8
1-acylglycerol-3-phosphate O-acyltransferase 9
GPAT-3
MAG-1
acyl-CoA:glycerol-3-phosphate acyltransferase 3
endoplasmic reticulum associated GPAT
hGPAT3
lung cancer metastasis-associated protein 1
lysophosphatidic acid acyltransferase theta
testis secretory sperm-binding protein Li 213e
NP_001243350.1
NP_001243351.1
NP_116106.2
XP_011530685.1
XP_011530686.1
XP_016864269.1
XP_016864270.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256421.1NP_001243350.1  glycerol-3-phosphate acyltransferase 3

    See identical proteins and their annotated locations for NP_001243350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC021192, AC096768, AK055749, BM841009
    Consensus CDS
    CCDS3606.1
    UniProtKB/Swiss-Prot
    Q53EU6
    UniProtKB/TrEMBL
    A0A024RDG5
    Related
    ENSP00000378651.2, ENST00000395226.6
    Conserved Domains (1) summary
    cd07991
    Location:199408
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
  2. NM_001256422.1NP_001243351.1  glycerol-3-phosphate acyltransferase 3

    See identical proteins and their annotated locations for NP_001243351.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC021192, BM841009, DA393801
    Consensus CDS
    CCDS3606.1
    UniProtKB/Swiss-Prot
    Q53EU6
    UniProtKB/TrEMBL
    A0A024RDG5
    Related
    ENSP00000482571.1, ENST00000611707.4
    Conserved Domains (1) summary
    cd07991
    Location:199408
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
  3. NM_032717.5NP_116106.2  glycerol-3-phosphate acyltransferase 3

    See identical proteins and their annotated locations for NP_116106.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC096768, AY358100, BM841009, DA673378
    Consensus CDS
    CCDS3606.1
    UniProtKB/Swiss-Prot
    Q53EU6
    UniProtKB/TrEMBL
    A0A024RDG5
    Related
    ENSP00000264409.4, ENST00000264409.5
    Conserved Domains (1) summary
    cd07991
    Location:199408
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    83535634..83605875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008780.1XP_016864269.1  glycerol-3-phosphate acyltransferase 3 isoform X1

  2. XM_017008781.1XP_016864270.1  glycerol-3-phosphate acyltransferase 3 isoform X2

    UniProtKB/Swiss-Prot
    Q53EU6
    UniProtKB/TrEMBL
    A0A024RDG5
    Conserved Domains (1) summary
    cd07991
    Location:199408
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
  3. XM_011532384.2XP_011530686.1  glycerol-3-phosphate acyltransferase 3 isoform X3

    See identical proteins and their annotated locations for XP_011530686.1

    Conserved Domains (1) summary
    cd07991
    Location:121330
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
  4. XM_011532383.2XP_011530685.1  glycerol-3-phosphate acyltransferase 3 isoform X3

    See identical proteins and their annotated locations for XP_011530685.1

    Conserved Domains (1) summary
    cd07991
    Location:121330
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
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