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RAE1 ribonucleic acid export 1 [ Homo sapiens (human) ]

Gene ID: 8480, updated on 7-Jun-2020

Summary

Official Symbol
RAE1provided by HGNC
Official Full Name
ribonucleic acid export 1provided by HGNC
Primary source
HGNC:HGNC:9828
See related
Ensembl:ENSG00000101146 MIM:603343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gle2; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1
Summary
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 35.7), bone marrow (RPKM 13.2) and 24 other tissues See more
Orthologs

Genomic context

See RAE1 in Genome Data Viewer
Location:
20q13.31
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (57351239..57379202)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (55926145..55953519)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372687 Neighboring gene ribosomal protein L39 pseudogene 39 Neighboring gene SPO11 initiator of meiotic double stranded breaks Neighboring gene nuclear-encoded mitochondrial tRNA-Leu (TAA) 5-1 Neighboring gene MT-RNR2 like 3 Neighboring gene MT-ND1 pseudogene 9 Neighboring gene RBM38 antisense RNA 1 Neighboring gene RNA binding motif protein 38 Neighboring gene VISTA enhancer hs1971

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30608, MGC117333, MGC126076, MGC126077

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
intracellular transport of virus TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of glycolytic process TAS
Traceable Author Statement
more info
 
regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
host cell IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle pole IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mRNA export factor
Names
RAE1 RNA export 1 homolog
homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer)
mRNA export protein
mRNA-associated protein MRNP 41
mRNA-binding protein, 41-kD
migration-inducing gene 14
rae1 protein homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047090.1 RefSeqGene

    Range
    5167..33114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015885.1NP_001015885.1  mRNA export factor

    See identical proteins and their annotated locations for NP_001015885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AI341915, AY349350, U84720
    Consensus CDS
    CCDS13458.1
    UniProtKB/Swiss-Prot
    P78406
    Related
    ENSP00000379181.2, ENST00000395840.6
    Conserved Domains (2) summary
    sd00039
    Location:4284
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:40335
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_003610.4NP_003601.1  mRNA export factor

    See identical proteins and their annotated locations for NP_003601.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs from variant 2 in the 5' UTR and encodes the same protein as variant 2.
    Source sequence(s)
    AI341915, AL109955, AL135939, AY349350, U84720
    Consensus CDS
    CCDS13458.1
    UniProtKB/Swiss-Prot
    P78406
    Related
    ENSP00000379182.2, ENST00000395841.7
    Conserved Domains (2) summary
    sd00039
    Location:4284
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:40335
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    57351239..57379202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028108.2XP_016883597.1  mRNA export factor isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:39337
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:4284
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:40335
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_005260582.2XP_005260639.2  mRNA export factor isoform X1

    See identical proteins and their annotated locations for XP_005260639.2

    UniProtKB/Swiss-Prot
    P78406
    Related
    ENSP00000360286.2, ENST00000371242.6
    Conserved Domains (2) summary
    sd00039
    Location:4284
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:40335
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_011529087.2XP_011527389.1  mRNA export factor isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:39337
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:4284
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:40335
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_005260583.2XP_005260640.1  mRNA export factor isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:77375
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:80122
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78373
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_011529088.2XP_011527390.1  mRNA export factor isoform X1

    See identical proteins and their annotated locations for XP_011527390.1

    UniProtKB/Swiss-Prot
    P78406
    Conserved Domains (2) summary
    sd00039
    Location:4284
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:40335
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_011529089.1XP_011527391.1  mRNA export factor isoform X1

    See identical proteins and their annotated locations for XP_011527391.1

    UniProtKB/Swiss-Prot
    P78406
    Conserved Domains (2) summary
    sd00039
    Location:4284
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:40335
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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