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FAM220A family with sequence similarity 220 member A [ Homo sapiens (human) ]

Gene ID: 84792, updated on 5-Jan-2022

Summary

Official Symbol
FAM220Aprovided by HGNC
Official Full Name
family with sequence similarity 220 member Aprovided by HGNC
Primary source
HGNC:HGNC:22422
See related
Ensembl:ENSG00000178397 MIM:616628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIPAR; ACPIN1; C7orf70
Summary
Predicted to enable STAT family protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein dephosphorylation. Predicted to act upstream of or within positive regulation of protein binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in testis (RPKM 42.1), brain (RPKM 9.5) and 22 other tissues See more
Orthologs
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Genomic context

See FAM220A in Genome Data Viewer
Location:
7p22.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (6329411..6348967, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6369042..6388598, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 42 Neighboring gene cytohesin 3 Neighboring gene salivary gland specific protein SAGSIN1 Neighboring gene ribosomal protein SA pseudogene 73 Neighboring gene Rac family small GTPase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12966

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables STAT family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein FAM220A
Names
STAT3-interacting protein as a repressor
acrosomal protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037163.2NP_001032240.1  protein FAM220A

    See identical proteins and their annotated locations for NP_001032240.1

    Status: VALIDATED

    Source sequence(s)
    AC009412, AF533707, BP354450
    Consensus CDS
    CCDS34599.1
    UniProtKB/Swiss-Prot
    Q7Z4H9
    Related
    ENSP00000317289.4, ENST00000313324.9
    Conserved Domains (1) summary
    pfam15487
    Location:2253
    FAM220; FAM220 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    6329411..6348967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032706.1: Suppressed sequence

    Description
    NM_032706.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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