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KMT5C lysine methyltransferase 5C [ Homo sapiens (human) ]

Gene ID: 84787, updated on 17-Jun-2019

Summary

Official Symbol
KMT5Cprovided by HGNC
Official Full Name
lysine methyltransferase 5Cprovided by HGNC
Primary source
HGNC:HGNC:28405
See related
Ensembl:ENSG00000133247 MIM:613198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUV420H2; Suv4-20h2
Summary
SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 1.9), placenta (RPKM 1.5) and 25 other tissues See more
Orthologs

Genomic context

See KMT5C in Genome Data Viewer
Location:
19q13.42
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (55339876..55348121)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55851221..55859489)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene HSPA (Hsp70) binding protein 1 Neighboring gene BR serine/threonine kinase 1 Neighboring gene transmembrane protein 150B Neighboring gene cytochrome c oxidase subunit 6B2 Neighboring gene family with sequence similarity 71 member E2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • Histone Modifications, organism-specific biosystem (from WikiPathways)
    Histone Modifications, organism-specific biosystemHistones can undergo many post-translational modifications that are involved in transcription regulation. This pathway provides an overview of various modifications for histones H3 and H4 and the en...
  • Lysine degradation, organism-specific biosystem (from KEGG)
    Lysine degradation, organism-specific biosystem
    Lysine degradation
  • Lysine degradation, conserved biosystem (from KEGG)
    Lysine degradation, conserved biosystem
    Lysine degradation
  • PKMTs methylate histone lysines, organism-specific biosystem (from REACTOME)
    PKMTs methylate histone lysines, organism-specific biosystemLysine methyltransferases (KMTs) and arginine methyltransferases (RMTs) have a common mechanism of catalysis. Both families transfer a methyl group from a common donor, S-adenosyl-L-methionine (SAM),...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2705, FLJ51466, FLJ98627

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone methyltransferase activity (H4-K20 specific) IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone H4-K20 trimethylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
condensed nuclear chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone-lysine N-methyltransferase KMT5C
Names
histone-lysine N-methyltransferase SUV420H2
lysine (K)-specific methyltransferase 5C
lysine N-methyltransferase 5C
lysine-specific methyltransferase 5C
su(var)4-20 homolog 2
suppressor of variegation 4-20 homolog 2
NP_116090.2
XP_005259395.1
XP_006723505.1
XP_011525717.1
XP_016882877.1
XP_024307510.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032701.4NP_116090.2  histone-lysine N-methyltransferase KMT5C

    See identical proteins and their annotated locations for NP_116090.2

    Status: VALIDATED

    Source sequence(s)
    AK308586, AW248704, BC044889
    Consensus CDS
    CCDS12922.1
    UniProtKB/Swiss-Prot
    Q86Y97
    Related
    ENSP00000255613.3, ENST00000255613.8
    Conserved Domains (1) summary
    smart00317
    Location:120224
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    55339876..55348121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027388.2XP_016882877.1  histone-lysine N-methyltransferase KMT5C isoform X3

    Conserved Domains (1) summary
    pfam00856
    Location:3154
    SET; SET domain
  2. XM_005259338.4XP_005259395.1  histone-lysine N-methyltransferase KMT5C isoform X2

    See identical proteins and their annotated locations for XP_005259395.1

    UniProtKB/Swiss-Prot
    Q86Y97
    UniProtKB/TrEMBL
    A0A0D9SF94
    Related
    ENSP00000486397.1, ENST00000630497.1
    Conserved Domains (1) summary
    smart00317
    Location:5109
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  3. XM_024451742.1XP_024307510.1  histone-lysine N-methyltransferase KMT5C isoform X2

    Conserved Domains (1) summary
    smart00317
    Location:5109
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  4. XM_011527415.3XP_011525717.1  histone-lysine N-methyltransferase KMT5C isoform X1

    See identical proteins and their annotated locations for XP_011525717.1

    UniProtKB/Swiss-Prot
    Q86Y97
    Conserved Domains (1) summary
    smart00317
    Location:120224
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  5. XM_006723442.3XP_006723505.1  histone-lysine N-methyltransferase KMT5C isoform X2

    See identical proteins and their annotated locations for XP_006723505.1

    UniProtKB/Swiss-Prot
    Q86Y97
    UniProtKB/TrEMBL
    A0A0D9SF94
    Conserved Domains (1) summary
    smart00317
    Location:5109
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
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