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NAA11 N-alpha-acetyltransferase 11, NatA catalytic subunit [ Homo sapiens (human) ]

Gene ID: 84779, updated on 5-Aug-2022

Summary

Official Symbol
NAA11provided by HGNC
Official Full Name
N-alpha-acetyltransferase 11, NatA catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:28125
See related
Ensembl:ENSG00000156269 MIM:619432; AllianceGenome:HGNC:28125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARD2; ARD1B; hARD2
Summary
Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation. Located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Part of NatA complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 1.1) and placenta (RPKM 0.8) See more
Orthologs
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Genomic context

See NAA11 in Genome Data Viewer
Location:
4q21.21
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (79155376..79326061, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (82652425..82661846, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (80237801..80247215, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene BMP2 inducible kinase Neighboring gene RNA, 7SL, cytoplasmic 127, pseudogene Neighboring gene progestin and adipoQ receptor family member 3 Neighboring gene long intergenic non-protein coding RNA 1088 Neighboring gene uncharacterized LOC124900723 Neighboring gene uncharacterized LOC105377300 Neighboring gene glycerol kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10646

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptide alpha-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide-glutamate-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide-serine-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NatA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NatA complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
N-alpha-acetyltransferase 11
Names
=N-terminal acetyltransferase complex ARD1 subunit homolog B
ARD1 homolog B
N-terminal acetyltransferase complex ARD1 subunit homolog B
human arrest defective 2
natA catalytic subunit Naa11
NP_116082.1
XP_016864266.1
XP_016864267.1
XP_016864268.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032693.3NP_116082.1  N-alpha-acetyltransferase 11

    See identical proteins and their annotated locations for NP_116082.1

    Status: VALIDATED

    Source sequence(s)
    AC023277, BC004552
    Consensus CDS
    CCDS47084.1
    UniProtKB/Swiss-Prot
    Q6P479, Q9BSU3
    Related
    ENSP00000286794.4, ENST00000286794.5
    Conserved Domains (2) summary
    COG0456
    Location:1149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:47122
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    79155376..79326061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008779.2XP_016864268.1  N-alpha-acetyltransferase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q6P479, Q9BSU3
    Conserved Domains (2) summary
    COG0456
    Location:1149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:47122
    Acetyltransf_1; Acetyltransferase (GNAT) family
  2. XM_017008778.3XP_016864267.1  N-alpha-acetyltransferase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q6P479, Q9BSU3
    Conserved Domains (2) summary
    COG0456
    Location:1149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:47122
    Acetyltransf_1; Acetyltransferase (GNAT) family
  3. XM_017008777.2XP_016864266.1  N-alpha-acetyltransferase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q6P479, Q9BSU3
    Conserved Domains (2) summary
    COG0456
    Location:1149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:47122
    Acetyltransf_1; Acetyltransferase (GNAT) family

RNA

  1. XR_007057978.1 RNA Sequence

  2. XR_001741340.2 RNA Sequence

  3. XR_001741339.2 RNA Sequence

  4. XR_007057977.1 RNA Sequence

  5. XR_007057979.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    82652425..82661846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)