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GPR65 G protein-coupled receptor 65 [ Homo sapiens (human) ]

Gene ID: 8477, updated on 4-Jun-2020

Summary

Official Symbol
GPR65provided by HGNC
Official Full Name
G protein-coupled receptor 65provided by HGNC
Primary source
HGNC:HGNC:4517
See related
Ensembl:ENSG00000140030 MIM:604620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDAG8; hTDAG8
Expression
Broad expression in appendix (RPKM 6.3), bone marrow (RPKM 5.3) and 18 other tissues See more
Orthologs

Genomic context

See GPR65 in Genome Data Viewer
Location:
14q31.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (88005135..88014811)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88471468..88481155)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene galactosylceramidase Neighboring gene shieldin complex subunit 2 pseudogene 2 Neighboring gene RNA, U6 small nuclear 835, pseudogene Neighboring gene uncharacterized LOC107984669 Neighboring gene long intergenic non-protein coding RNA 1147 Neighboring gene long intergenic non-protein coding RNA 1146 Neighboring gene uncharacterized LOC107984699

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
psychosine receptor
Names
T-cell death-associated gene 8 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003608.4NP_003599.2  psychosine receptor

    See identical proteins and their annotated locations for NP_003599.2

    Status: VALIDATED

    Source sequence(s)
    AL157955
    Consensus CDS
    CCDS9879.1
    UniProtKB/Swiss-Prot
    Q8IYL9
    UniProtKB/TrEMBL
    B5B0C2
    Related
    ENSP00000267549.3, ENST00000267549.5
    Conserved Domains (1) summary
    cd15365
    Location:15301
    7tmA_GPR65_TDAG8; proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    88005135..88014811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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