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GPR65 G protein-coupled receptor 65 [ Homo sapiens (human) ]

Gene ID: 8477, updated on 4-Jun-2020

Summary

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Official Symbol
GPR65provided by HGNC
Official Full Name
G protein-coupled receptor 65provided by HGNC
Primary source
HGNC:HGNC:4517
See related
Ensembl:ENSG00000140030 MIM:604620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDAG8; hTDAG8
Expression
Broad expression in appendix (RPKM 6.3), bone marrow (RPKM 5.3) and 18 other tissues See more
Orthologs
mouse all

Genomic context

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See GPR65 in Genome Data Viewer
Location:
14q31.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (88005135..88014811)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88471468..88481155)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene galactosylceramidase Neighboring gene shieldin complex subunit 2 pseudogene 2 Neighboring gene RNA, U6 small nuclear 835, pseudogene Neighboring gene uncharacterized LOC107984669 Neighboring gene long intergenic non-protein coding RNA 1147 Neighboring gene long intergenic non-protein coding RNA 1146 Neighboring gene uncharacterized LOC107984699

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation. Tcymbarevich IV, et al. BMC Gastroenterol, 2019 Jan 7. PMID 30616622, Free PMC Article
  2. Genetic polymorphisms of G protein-coupled receptor 65 gene are associated with ankylosing spondylitis in a Chinese Han population: A case-control study. Yuan Y, et al. Hum Immunol, 2019 Feb. PMID 30529363
  3. Overexpression of G-protein-coupled receptors 65 in glioblastoma predicts poor patient prognosis. Wang HX, et al. Clin Neurol Neurosurg, 2018 Jan. PMID 29223793
  4. Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies. Justus CR, et al. J Transl Med, 2017 Oct 10. PMID 29017562, Free PMC Article
  5. Acid-sensing T cell death associated gene-8 receptor expression in panic disorder. Strawn JR, et al. Brain Behav Immun, 2018 Jan. PMID 28736033, Free PMC Article

See all (28) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that genetic polymorphisms of G protein-coupled receptor 65 gene are associated with ankylosing spondylitis in a Chinese Han population
    Title: Genetic polymorphisms of G protein-coupled receptor 65 gene are associated with ankylosing spondylitis in a Chinese Han population: A case-control study.
  2. Panic disorder (PD) patients appear to display polymorphisms in the ACCN gene and elevated levels of TDAG8 mRNA. [systematic review, meta-analysis ]
    Title: The role of acid-sensitive ion channels in panic disorder: a systematic review of animal studies and meta-analysis of human studies.
  3. we confirmed a significant association between the rare homozygote rs8005161 TT genotype and a diagnosis of ulcerative colitis. Our study did not identify biochemical changes in individuals with various genotypes of rs8005161, however we identified a lower activation of RhoA upon an acidic pH shift in inflammatory bowel disease patients.
    Title: The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.
  4. GPR65 is overexpressed in glioblastoma and its high expression predicts unfavorable clinical outcome for patients.
    Title: Overexpression of G-protein-coupled receptors 65 in glioblastoma predicts poor patient prognosis.
  5. TDAG8 functions as a contextual tumor suppressor down-regulated in hematological malignancies.
    Title: Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies.
  6. Study results suggest greater T cell death associated gene-8 (TDAG8) expression in patients with panic disorder compared to healthy subjects, and directly link TDAG8 expression and the severity of the panic disorder symptoms
    Title: Acid-sensing T cell death associated gene-8 receptor expression in panic disorder.
  7. this study establishes a role for GPR65 in inflammatory bowel disease susceptibility and identify lysosomal dysfunction as a potentially causative element in pathogenesis
    Title: Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.
  8. TDAG8 expression is decreased by more than 50%.
    Title: Acidosis decreases c-Myc oncogene expression in human lymphoma cells: a role for the proton-sensing G protein-coupled receptor TDAG8.
  9. GPR65 is a regulator upstream of MMP3, which is regulated by proton-sensing G-protein-coupled receptors
    Title: Identification of GPR65, a novel regulator of matrix metalloproteinases using high through-put screening.
  10. Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk.
    Title: Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
 PubMed 
activation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
  
immune response TAS
Traceable Author Statement
more info
 PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
 PubMed 
positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
 PubMed 
response to acidic pH IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
psychosine receptor
Names
T-cell death-associated gene 8 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003608.4 → NP_003599.2  psychosine receptor

    See identical proteins and their annotated locations for NP_003599.2

    Status: VALIDATED

    Source sequence(s)
    AL157955
    Consensus CDS
    CCDS9879.1
    UniProtKB/Swiss-Prot
    Q8IYL9
    UniProtKB/TrEMBL
    B5B0C2
    Related
    ENSP00000267549.3, ENST00000267549.5
    Conserved Domains (1) summary
    cd15365
    Location:15 → 301
    7tmA_GPR65_TDAG8; proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    88005135..88014811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IYL9.1 GenPept UniProtKB/Swiss-Prot:Q8IYL9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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