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PCGF1 polycomb group ring finger 1 [ Homo sapiens (human) ]

Gene ID: 84759, updated on 25-Nov-2021

Summary

Official Symbol
PCGF1provided by HGNC
Official Full Name
polycomb group ring finger 1provided by HGNC
Primary source
HGNC:HGNC:17615
See related
Ensembl:ENSG00000115289 MIM:610231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSPC1; RNF68; RNF3A-2; 2010002K04Rik
Summary
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008]
Expression
Ubiquitous expression in thyroid (RPKM 3.8), testis (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

See PCGF1 in Genome Data Viewer
Location:
2p13.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (74505043..74507695, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74732170..74734822, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 31 Neighboring gene ladybird homeobox 2 Neighboring gene Sharpr-MPRA regulatory region 184 Neighboring gene LBX2 antisense RNA 1 Neighboring gene T cell leukemia homeobox 2 Neighboring gene DEAQ-box RNA dependent ATPase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of polycomb group ring finger 1 (PCGF1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43754, MGC10882

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polycomb group RING finger protein 1
Names
RING finger protein 68
nervous system Polycomb-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032673.3NP_116062.2  polycomb group RING finger protein 1

    See identical proteins and their annotated locations for NP_116062.2

    Status: VALIDATED

    Source sequence(s)
    AC005041, BC004952, BU602498
    Consensus CDS
    CCDS1946.2
    UniProtKB/Swiss-Prot
    Q9BSM1
    Related
    ENSP00000233630.6, ENST00000233630.11
    Conserved Domains (2) summary
    cd16733
    Location:4486
    RING-HC_PCGF1; RING finger, HC subclass, found in polycomb group RING finger protein 1 (PCGF1) and similar proteins
    cd17081
    Location:166253
    RAWUL_PCGF1; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 1 (PCGF1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    74505043..74507695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453181.1XP_024308949.1  polycomb group RING finger protein 1 isoform X1

    Conserved Domains (1) summary
    pfam16207
    Location:107170
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
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