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POFUT3 protein O-fucosyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 84750, updated on 6-Jul-2026
Official Symbol
POFUT3provided by HGNC
Official Full Name
protein O-fucosyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:19234
See related
Ensembl:ENSG00000172728 MIM:616931; AllianceGenome:HGNC:19234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FUCTX; FUT10
Summary
Enables fucosyltransferase activity. Involved in N-glycan fucosylation. Located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in ovary (RPKM 2.0), placenta (RPKM 1.5) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See POFUT3 in Genome Data Viewer
Location:
8p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (33308061..33473146, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (33578178..33744498, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (33228342..33330664, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379362 Neighboring gene MT-ND2 pseudogene 32 Neighboring gene RAN pseudogene 9 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:32986477-32987676 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:33201768-33202321 Neighboring gene NANOG hESC enhancer GRCh37_chr8:33210014-33210633 Neighboring gene RNA, U6 small nuclear 528, pseudogene Neighboring gene RNA binding motif protein 4 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:33341856-33342492 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:33342520-33342707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27220 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene MAK16 homolog Neighboring gene TELO2 interacting protein 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse. Baboval T, et al. Mamm Genome, 2002 Sep. PMID 12370785
  2. FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains. Hao H, et al. Nat Chem Biol, 2025 Apr. PMID 39775168, Free PMC Article
  3. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). Mollicone R, et al. J Biol Chem, 2009 Feb 13. PMID 19088067
  4. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, et al. J Biol Chem, 2002 Feb 1. PMID 11698403
  5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse.
    Title: Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  3. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).
    Title: Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC11141

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-(1->3)-fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-(1->3)-fucosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables fucosyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-O-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-O-fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-fucose catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in N-glycan processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-glycan processing IEA
Inferred from Electronic Annotation
more info
  
involved_in fertilization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glycoprotein biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycoprotein biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in neuronal stem cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in neuronal stem cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation TAS
Traceable Author Statement
more info
  
involved_in protein folding NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein targeting NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in wound healing NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus EXP
Inferred from Experiment
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus TAS
Traceable Author Statement
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in lysosome EXP
Inferred from Experiment
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
GDP-fucose protein O-fucosyltransferase 3
Names
alpha (1,3) fucosyltransferase
alpha 1,3-fucosyl transferase
alpha-(1,3)-fucosyltransferase 10
fuc-TX
fucT-X
fucosyltransferase 10
fucosyltransferase X
galactoside 3-L-fucosyltransferase 10
NP_116053.3
XP_011542978.1
XP_011542979.1
XP_011542981.1
XP_011542982.1
XP_011542983.1
XP_047278281.1
XP_047278282.1
XP_054217345.1
XP_054217346.1
XP_054217347.1
XP_054217348.1
XP_054217349.1
XP_054217350.1
XP_054217351.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032664.3 → NP_116053.3  GDP-fucose protein O-fucosyltransferase 3

    See identical proteins and their annotated locations for NP_116053.3

    Status: VALIDATED

    Source sequence(s)
    AJ582015, BC063462
    Consensus CDS
    CCDS6088.1
    UniProtKB/Swiss-Prot
    A8KAC8, Q6P4F1, Q70GG3, Q8IVI6, Q8IVI7, Q8IVJ3, Q8TE43, Q9BSR3
    UniProtKB/TrEMBL
    B4DLS4
    Related
    ENSP00000332757.5, ENST00000327671.10
    Conserved Domains (2) summary
    pfam00852
    Location:219 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:83 → 177
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    33308061..33473146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544677.4 → XP_011542979.1  GDP-fucose protein O-fucosyltransferase 3 isoform X2

    UniProtKB/TrEMBL
    B4DLS4
    Conserved Domains (2) summary
    pfam00852
    Location:219 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:83 → 177
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  2. XM_011544676.4 → XP_011542978.1  GDP-fucose protein O-fucosyltransferase 3 isoform X1

    UniProtKB/TrEMBL
    B4DLS4
    Conserved Domains (2) summary
    pfam00852
    Location:261 → 396
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:125 → 219
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  3. XM_047422325.1 → XP_047278281.1  GDP-fucose protein O-fucosyltransferase 3 isoform X3

    UniProtKB/TrEMBL
    B4DLS4

  4. XM_011544681.4 → XP_011542983.1  GDP-fucose protein O-fucosyltransferase 3 isoform X6

    UniProtKB/TrEMBL
    B4DLS4
    Conserved Domains (2) summary
    pfam00852
    Location:261 → 396
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:125 → 219
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  5. XM_047422326.1 → XP_047278282.1  GDP-fucose protein O-fucosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    B4DLS4

  6. XM_011544679.4 → XP_011542981.1  GDP-fucose protein O-fucosyltransferase 3 isoform X4

    UniProtKB/TrEMBL
    B4DLS4
    Conserved Domains (2) summary
    pfam00852
    Location:261 → 396
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:125 → 219
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  7. XM_011544680.4 → XP_011542982.1  GDP-fucose protein O-fucosyltransferase 3 isoform X5

    UniProtKB/TrEMBL
    B4DLS4
    Conserved Domains (2) summary
    pfam00852
    Location:261 → 396
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:125 → 219
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    33578178..33744498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361370.1 → XP_054217345.1  GDP-fucose protein O-fucosyltransferase 3 isoform X1

    UniProtKB/TrEMBL
    B4DLS4

  2. XM_054361372.1 → XP_054217347.1  GDP-fucose protein O-fucosyltransferase 3 isoform X3

    UniProtKB/TrEMBL
    B4DLS4

  3. XM_054361371.1 → XP_054217346.1  GDP-fucose protein O-fucosyltransferase 3 isoform X2

    UniProtKB/TrEMBL
    B4DLS4

  4. XM_054361375.1 → XP_054217350.1  GDP-fucose protein O-fucosyltransferase 3 isoform X6

    UniProtKB/TrEMBL
    B4DLS4

  5. XM_054361376.1 → XP_054217351.1  GDP-fucose protein O-fucosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    B4DLS4

  6. XM_054361373.1 → XP_054217348.1  GDP-fucose protein O-fucosyltransferase 3 isoform X4

    UniProtKB/TrEMBL
    B4DLS4

  7. XM_054361374.1 → XP_054217349.1  GDP-fucose protein O-fucosyltransferase 3 isoform X5

    UniProtKB/TrEMBL
    B4DLS4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P4F1.2 GenPept UniProtKB/Swiss-Prot:Q6P4F1

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