Format

Send to:

Choose Destination

OGT O-linked N-acetylglucosamine (GlcNAc) transferase [ Homo sapiens (human) ]

Gene ID: 8473, updated on 11-Nov-2018

Summary

Official Symbol
OGTprovided by HGNC
Official Full Name
O-linked N-acetylglucosamine (GlcNAc) transferaseprovided by HGNC
Primary source
HGNC:HGNC:8127
See related
Ensembl:ENSG00000147162 MIM:300255; Vega:OTTHUMG00000033316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OGT1; HRNT1; MRX106; HINCUT-1; O-GLCNAC
Summary
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in lymph node (RPKM 56.6), spleen (RPKM 53.1) and 25 other tissues See more
Orthologs

Genomic context

See OGT in Genome Data Viewer
Location:
Xq13.1
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (71533062..71575897)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70752912..70795747)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 1 Neighboring gene inhibitor of growth family, X-linked (pseudogene) Neighboring gene suppressor of cytokine signaling 6 pseudogene Neighboring gene germ cell nuclear acidic peptidase Neighboring gene C-X-C motif chemokine receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Other types of O-glycan biosynthesis, organism-specific biosystem (from KEGG)
    Other types of O-glycan biosynthesis, organism-specific biosystemO-linked glycosylation is the attachment of monosaccharides to the hydroxyl groups of amino acids, mostly serine and threonine, and is found in eukaryotes, archaea and bacteria. O-glycans exhibit div...
  • Other types of O-glycan biosynthesis, conserved biosystem (from KEGG)
    Other types of O-glycan biosynthesis, conserved biosystemO-linked glycosylation is the attachment of monosaccharides to the hydroxyl groups of amino acids, mostly serine and threonine, and is found in eukaryotes, archaea and bacteria. O-glycans exhibit div...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • UCH proteinases, organism-specific biosystem (from REACTOME)
    UCH proteinases, organism-specific biosystemDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Hu...
  • protein O-[N-acetyl]-glucosylation, organism-specific biosystem (from BIOCYC)
    protein O-[N-acetyl]-glucosylation, organism-specific biosystemThe most abundant type of O glycosylation in proteins is the GalNAc-type, where : CPD-3604 is linked to : SER or : THR residues in the protein chain by an alpha-glycosidic linkage. In most cases othe...
  • protein O-[N-acetyl]-glucosylation, conserved biosystem (from BIOCYC)
    protein O-[N-acetyl]-glucosylation, conserved biosystemThe most abundant type of O glycosylation in proteins is the GalNAc-type, where |FRAME: CPD-3604| is linked to |FRAME: SER| or |FRAME: THR| residues in the protein chain by an alpha-glycosidic linkag...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23071, MGC22921

Gene Ontology Provided by GOA

Process Evidence Code Pubs
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3-K4 trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of histone H3-K27 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Rac protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to insulin IDA
Inferred from Direct Assay
more info
PubMed 
response to nutrient TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Names
O-GlcNAc transferase p110 subunit
O-GlcNAc transferase subunit p110
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
O-linked N-acetylglucosamine transferase 110 kDa subunit
UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
NP_858058.1
NP_858059.1
XP_016885397.1
XP_024308235.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015875.1 RefSeqGene

    Range
    5001..47836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181672.2NP_858058.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

    See identical proteins and their annotated locations for NP_858058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF070560, AL590763, BC038180, BX537844, CB857907, DA460761
    Consensus CDS
    CCDS14414.1
    UniProtKB/Swiss-Prot
    O15294
    Related
    ENSP00000362824.3, OTTHUMP00000032154, ENST00000373719.7, OTTHUMT00000081829
    Conserved Domains (3) summary
    sd00006
    Location:327355
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:5561023
    Glyco_transf_41; Glycosyl transferase family 41
    cl26002
    Location:22465
    TPR_11; TPR repeat
  2. NM_181673.2NP_858059.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

    See identical proteins and their annotated locations for NP_858059.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AL590763, BC014434, BX537844, CB857907, DA460761
    Consensus CDS
    CCDS35502.1
    UniProtKB/Swiss-Prot
    O15294
    Related
    ENSP00000362805.3, OTTHUMP00000032166, ENST00000373701.7, OTTHUMT00000081847
    Conserved Domains (3) summary
    sd00006
    Location:317345
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:5461013
    Glyco_transf_41; Glycosyl transferase family 41
    cl26002
    Location:23455
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    71533062..71575897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029908.1XP_016885397.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1

    UniProtKB/Swiss-Prot
    O15294
    Conserved Domains (3) summary
    COG0457
    Location:2121
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1442
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:175642
    Glyco_transf_41; Glycosyl transferase family 41
  2. XM_024452467.1XP_024308235.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1

    Conserved Domains (3) summary
    COG0457
    Location:2121
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1442
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:175642
    Glyco_transf_41; Glycosyl transferase family 41

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003605.3: Suppressed sequence

    Description
    NM_003605.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center