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OGT O-linked N-acetylglucosamine (GlcNAc) transferase [ Homo sapiens (human) ]

Gene ID: 8473, updated on 5-Apr-2020

Summary

Official Symbol
OGTprovided by HGNC
Official Full Name
O-linked N-acetylglucosamine (GlcNAc) transferaseprovided by HGNC
Primary source
HGNC:HGNC:8127
See related
Ensembl:ENSG00000147162 MIM:300255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OGT1; HRNT1; MRX106; HINCUT-1; O-GLCNAC
Summary
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in lymph node (RPKM 56.6), spleen (RPKM 53.1) and 25 other tissues See more
Orthologs

Genomic context

See OGT in Genome Data Viewer
Location:
Xq13.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (71533104..71575892)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70752912..70795747)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 1 Neighboring gene inhibitor of growth family, X-linked (pseudogene) Neighboring gene suppressor of cytokine signaling 6 pseudogene Neighboring gene germ cell nuclear acidic peptidase Neighboring gene C-X-C motif chemokine receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23071, MGC22921

Gene Ontology Provided by GOA

Process Evidence Code Pubs
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3-K4 trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of histone H3-K27 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Rac protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to insulin IDA
Inferred from Direct Assay
more info
PubMed 
response to nutrient TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein N-acetylglucosaminyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Names
O-GlcNAc transferase p110 subunit
O-GlcNAc transferase subunit p110
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
O-linked N-acetylglucosamine transferase 110 kDa subunit
UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
NP_858058.1
NP_858059.1
XP_016885397.1
XP_024308235.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015875.1 RefSeqGene

    Range
    5043..47831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181672.3NP_858058.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

    See identical proteins and their annotated locations for NP_858058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF070560, BC038180, BX537844, DA460761
    Consensus CDS
    CCDS14414.1
    UniProtKB/Swiss-Prot
    O15294
    Related
    ENSP00000362824.3, ENST00000373719.8
    Conserved Domains (3) summary
    sd00006
    Location:327355
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:5561023
    Glyco_transf_41; Glycosyl transferase family 41
    cl26002
    Location:22465
    TPR_11; TPR repeat
  2. NM_181673.3NP_858059.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

    See identical proteins and their annotated locations for NP_858059.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    BC014434, BX537844, DA460761
    Consensus CDS
    CCDS35502.1
    UniProtKB/Swiss-Prot
    O15294
    Related
    ENSP00000362805.3, ENST00000373701.7
    Conserved Domains (3) summary
    sd00006
    Location:317345
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:5461013
    Glyco_transf_41; Glycosyl transferase family 41
    cl26002
    Location:23455
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    71533104..71575892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029908.1XP_016885397.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1

    UniProtKB/Swiss-Prot
    O15294
    Related
    ENST00000488174.5
    Conserved Domains (3) summary
    COG0457
    Location:2121
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1442
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:175642
    Glyco_transf_41; Glycosyl transferase family 41
  2. XM_024452467.1XP_024308235.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1

    Conserved Domains (3) summary
    COG0457
    Location:2121
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1442
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:175642
    Glyco_transf_41; Glycosyl transferase family 41

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003605.3: Suppressed sequence

    Description
    NM_003605.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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