U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 [ Homo sapiens (human) ]

Gene ID: 84727, updated on 19-Sep-2024

Summary

Official Symbol
SPSB2provided by HGNC
Official Full Name
splA/ryanodine receptor domain and SOCS box containing 2provided by HGNC
Primary source
HGNC:HGNC:29522
See related
Ensembl:ENSG00000111671 MIM:611658; AllianceGenome:HGNC:29522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSB2; GRCC9
Summary
This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Broad expression in brain (RPKM 50.3), appendix (RPKM 44.2) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SPSB2 in Genome Data Viewer
Location:
12p13.31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6870935..6873303, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6880233..6882601, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6980099..6982467, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 3 Neighboring gene cell division cycle associated 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5885 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6960952-6961912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4186 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6974948-6975610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6975611-6976272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6979885-6980470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5888 Neighboring gene triosephosphate isomerase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4190 Neighboring gene uncharacterized LOC105369632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6992574-6993122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6993123-6993671 Neighboring gene ribosomal protein L13 pseudogene 5 Neighboring gene DSTN pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC2519, FLJ17395

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
SPRY domain-containing SOCS box protein 2
Names
SPRY domain-containing SOCS box protein SSB-2
gene-rich cluster protein C9

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013308.1 RefSeqGene

    Range
    5055..7423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146316.2NP_001139788.1  SPRY domain-containing SOCS box protein 2

    See identical proteins and their annotated locations for NP_001139788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same protein.
    Source sequence(s)
    BC071933, U47924
    Consensus CDS
    CCDS8567.1
    UniProtKB/Swiss-Prot
    B7Z4W1, D3DUT0, Q99619
    Related
    ENSP00000430872.1, ENST00000523102.5
    Conserved Domains (2) summary
    cd03719
    Location:222263
    SOCS_SSB2; SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
    cd12906
    Location:46217
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
  2. NM_001319670.2NP_001306599.1  SPRY domain-containing SOCS box protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate segment in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same protein.
    Source sequence(s)
    U47924
    Consensus CDS
    CCDS8567.1
    UniProtKB/Swiss-Prot
    B7Z4W1, D3DUT0, Q99619
    Conserved Domains (2) summary
    cd03719
    Location:222263
    SOCS_SSB2; SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
    cd12906
    Location:46217
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
  3. NM_032641.4NP_116030.1  SPRY domain-containing SOCS box protein 2

    See identical proteins and their annotated locations for NP_116030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the reference variant. Variants 1, 2, and 4 encode the same protein.
    Source sequence(s)
    BC002983, DT220163
    Consensus CDS
    CCDS8567.1
    UniProtKB/Swiss-Prot
    B7Z4W1, D3DUT0, Q99619
    Related
    ENSP00000428338.1, ENST00000524270.6
    Conserved Domains (2) summary
    cd03719
    Location:222263
    SOCS_SSB2; SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
    cd12906
    Location:46217
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    6870935..6873303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    6880233..6882601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001146317.1: Suppressed sequence

    Description
    NM_001146317.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence.