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COX4I2 cytochrome c oxidase subunit 4I2 [ Homo sapiens (human) ]

Gene ID: 84701, updated on 25-Nov-2021

Summary

Official Symbol
COX4I2provided by HGNC
Official Full Name
cytochrome c oxidase subunit 4I2provided by HGNC
Primary source
HGNC:HGNC:16232
See related
Ensembl:ENSG00000131055 MIM:607976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COX4; COX4B; COX4-2; COX4L2; COXIV-2; dJ857M17.2
Summary
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 32.5), lung (RPKM 10.0) and 6 other tissues See more
Orthologs
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Genomic context

See COX4I2 in Genome Data Viewer
Location:
20q11.21
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (31637856..31645009)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30225715..30232809)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr20.845 Neighboring gene CRISPRi-validated cis-regulatory element chr20.846 Neighboring gene Sharpr-MPRA regulatory region 4727 Neighboring gene VISTA enhancer hs2050 Neighboring gene BCL2 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Names
COX IV-2
cytochrome c oxidase subunit IV-like 2
NP_115998.2
XP_005260636.1
XP_005260637.1
XP_005260638.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012180.1 RefSeqGene

    Range
    5025..12119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032609.3NP_115998.2  cytochrome c oxidase subunit 4 isoform 2, mitochondrial

    See identical proteins and their annotated locations for NP_115998.2

    Status: REVIEWED

    Source sequence(s)
    AL117381
    Consensus CDS
    CCDS13187.1
    UniProtKB/Swiss-Prot
    Q96KJ9
    UniProtKB/TrEMBL
    H6SG14
    Related
    ENSP00000365243.3, ENST00000376075.4
    Conserved Domains (1) summary
    cd00922
    Location:39164
    Cyt_c_Oxidase_IV; Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    31637856..31645009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260581.3XP_005260638.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl02792
    Location:40126
    Cyt_c_Oxidase_IV; Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
  2. XM_005260580.4XP_005260637.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl02792
    Location:32125
    Cyt_c_Oxidase_IV; Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
  3. XM_005260579.4XP_005260636.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam02936
    Location:45175
    COX4; Cytochrome c oxidase subunit IV
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