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CREB3L3 cAMP responsive element binding protein 3 like 3 [ Homo sapiens (human) ]

Gene ID: 84699, updated on 23-Nov-2021

Summary

Official Symbol
CREB3L3provided by HGNC
Official Full Name
cAMP responsive element binding protein 3 like 3provided by HGNC
Primary source
HGNC:HGNC:18855
See related
Ensembl:ENSG00000060566 MIM:611998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CREBH; HYTG2; CREB-H; HYST1481
Summary
This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Biased expression in small intestine (RPKM 71.0), duodenum (RPKM 67.5) and 1 other tissue See more
Orthologs
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Genomic context

See CREB3L3 in Genome Data Viewer
Location:
19p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4153631..4173054)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4153628..4173051)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2607 Neighboring gene Sharpr-MPRA regulatory region 6873 Neighboring gene sirtuin 6 Neighboring gene ankyrin repeat domain 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126553, MGC126557

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 3-like protein 3
Names
CREB/ATF family transcription factor
cAMP-responsive element-binding protein, hepatic-specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271995.2NP_001258924.1  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform b

    See identical proteins and their annotated locations for NP_001258924.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB073612, AK313099
    Consensus CDS
    CCDS62500.1
    UniProtKB/Swiss-Prot
    Q68CJ9
    Related
    ENSP00000469355.1, ENST00000595923.5
    Conserved Domains (2) summary
    cd14689
    Location:243303
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    cl19878
    Location:168265
    DUF2207; Predicted membrane protein (DUF2207)
  2. NM_001271996.2NP_001258925.1  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform c

    See identical proteins and their annotated locations for NP_001258925.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AB073612, AK313099, BC143609, DA210258
    Consensus CDS
    CCDS62499.1
    UniProtKB/Swiss-Prot
    Q68CJ9
    Related
    ENSP00000472399.1, ENST00000602257.5
    Conserved Domains (1) summary
    cd14689
    Location:242302
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  3. NM_001271997.2NP_001258926.1  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region which results in a frameshift, compared to variant 1. The encoded isoform (d) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB073612, AK313099, BC143610, DA210258
    Consensus CDS
    CCDS62498.1
    UniProtKB/Swiss-Prot
    Q68CJ9
    Related
    ENSP00000470119.1, ENST00000602147.1
  4. NM_032607.3NP_115996.1  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform a

    See identical proteins and their annotated locations for NP_115996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB050902, AB073612, AK313099
    Consensus CDS
    CCDS12121.1
    UniProtKB/Swiss-Prot
    Q68CJ9
    Related
    ENSP00000078445.1, ENST00000078445.7
    Conserved Domains (2) summary
    cd14689
    Location:244304
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    cl19878
    Location:169266
    DUF2207; Predicted membrane protein (DUF2207)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4153631..4173054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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