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GJA10 gap junction protein alpha 10 [ Homo sapiens (human) ]

Gene ID: 84694, updated on 13-Mar-2020

Summary

Official Symbol
GJA10provided by HGNC
Official Full Name
gap junction protein alpha 10provided by HGNC
Primary source
HGNC:HGNC:16995
See related
Ensembl:ENSG00000135355 MIM:611924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CX62
Summary
Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
Orthologs

Genomic context

See GJA10 in Genome Data Viewer
Location:
6q15
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (89894469..89896120)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90604188..90605819)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 pseudogene 14 Neighboring gene G protein pathway suppressor 1 pseudogene Neighboring gene BTB domain and CNC homolog 2 Neighboring gene RN7SK pseudogene 110 Neighboring gene uncharacterized LOC105377890

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
gap junction channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell communication IEA
Inferred from Electronic Annotation
more info
 
detection of light stimulus involved in visual perception IEA
Inferred from Electronic Annotation
more info
 
gamete generation IEA
Inferred from Electronic Annotation
more info
 
synapse assembly IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
connexin complex IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
gap junction alpha-10 protein
Names
connexin 62
gap junction protein, alpha 10, 62kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032602.2NP_115991.1  gap junction alpha-10 protein

    See identical proteins and their annotated locations for NP_115991.1

    Status: VALIDATED

    Source sequence(s)
    AL353692
    Consensus CDS
    CCDS5025.1
    UniProtKB/Swiss-Prot
    Q969M2
    Related
    ENSP00000358358.1, ENST00000369352.1
    Conserved Domains (3) summary
    smart00037
    Location:4476
    CNX; Connexin homologues
    smart01089
    Location:167233
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:3235
    Connexin; Connexin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    89894469..89896120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017363815.1 Reference GRCh38.p13 PATCHES

    Range
    92157..93808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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