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MS4A14 membrane spanning 4-domains A14 [ Homo sapiens (human) ]

Gene ID: 84689, updated on 5-Jan-2022

Summary

Official Symbol
MS4A14provided by HGNC
Official Full Name
membrane spanning 4-domains A14provided by HGNC
Primary source
HGNC:HGNC:30706
See related
Ensembl:ENSG00000166928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MS4A16; NYD-SP21
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis (RPKM 42.8), lung (RPKM 3.7) and 1 other tissue See more
Orthologs
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Genomic context

See MS4A14 in Genome Data Viewer
Location:
11q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60396459..60417756)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60163932..60185229)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5454 Neighboring gene membrane spanning 4-domains A6E Neighboring gene membrane spanning 4-domains A7 Neighboring gene membrane spanning 4-domains A5 Neighboring gene membrane spanning 4-domains A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MS4A7

Homology

Clone Names

  • MGC49828, MGC104289

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
membrane-spanning 4-domains subfamily A member 14
Names
MS4A13 protein
membrane-spanning 4-domains, subfamily A, member 16
testes development-related NYD-SP21
testis development protein NYD-SP21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079692.3NP_001073160.1  membrane-spanning 4-domains subfamily A member 14 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 4, which results in a shorter protein (isoform 2), compared to isoform 4.
    Source sequence(s)
    AP003127, AY094611
    Consensus CDS
    CCDS41652.1
    UniProtKB/Swiss-Prot
    Q96JA4
    Related
    ENSP00000378453.2, ENST00000395005.6
    Conserved Domains (1) summary
    pfam04103
    Location:44130
    CD20; CD20-like family
  2. NM_001261827.2NP_001248756.1  membrane-spanning 4-domains subfamily A member 14 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, compared to variant 4, which results in a shorter protein (isoform 3), compared to isoform 4.
    Source sequence(s)
    AK057418, AP003127, DB082055
    Consensus CDS
    CCDS73295.1
    UniProtKB/TrEMBL
    A0A0A0MS57
    Related
    ENSP00000378449.2, ENST00000395001.5
    Conserved Domains (1) summary
    pfam04103
    Location:44130
    CD20; CD20-like family
  3. NM_001261828.2NP_001248757.1  membrane-spanning 4-domains subfamily A member 14 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AP003127, BC064627, DB727789
    Consensus CDS
    CCDS58136.1
    UniProtKB/Swiss-Prot
    Q96JA4
    Related
    ENSP00000433761.1, ENST00000531783.5
    Conserved Domains (1) summary
    pfam04103
    Location:44147
    CD20; CD20-like family
  4. NM_032597.5NP_115986.3  membrane-spanning 4-domains subfamily A member 14 isoform 1

    See identical proteins and their annotated locations for NP_115986.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has multiple coding region differences, compared to variant 4, which results in a shorter protein (isoform 1), compared to isoform 4.
    Source sequence(s)
    AP003127, AY094610
    Consensus CDS
    CCDS31569.1
    UniProtKB/Swiss-Prot
    Q96JA4
    Related
    ENSP00000300187.6, ENST00000300187.11
    Conserved Domains (1) summary
    pfam04103
    Location:44147
    CD20; CD20-like family

RNA

  1. NR_049731.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an alternate exon in the coding region, compared to variant 4, which results in the introduction of an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein product is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK057418, AP003127
    Related
    ENST00000530662.5
  2. NR_049732.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an alternate exon in the coding region, compared to variant 4, which results in the introduction of an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein product is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP003127, BC064627
    Related
    ENST00000525397.5
  3. NR_049733.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) includes an alternate exon in the coding region, compared to variant 4, which results in the introduction of an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein product is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK057418, AP003127, BC035361
    Related
    ENST00000527841.5
  4. NR_049734.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) includes an alternate exon in the coding region, compared to variant 4, which results in the introduction of an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein product is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP003127, DB450359

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60396459..60417756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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