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PPP1R9B protein phosphatase 1 regulatory subunit 9B [ Homo sapiens (human) ]

Gene ID: 84687, updated on 24-Nov-2020

Summary

Official Symbol
PPP1R9Bprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 9Bprovided by HGNC
Primary source
HGNC:HGNC:9298
See related
Ensembl:ENSG00000108819 MIM:603325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Spn; SPINO; PPP1R6; PPP1R9
Summary
This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in brain (RPKM 26.2), spleen (RPKM 25.4) and 24 other tissues See more
Orthologs

Genomic context

See PPP1R9B in Genome Data Viewer
Location:
17q21.33
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50133737..50150677, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48211101..48227877, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 3 Neighboring gene pyruvate dehydrogenase kinase 2 Neighboring gene sterile alpha motif domain containing 14 Neighboring gene Sharpr-MPRA regulatory region 5931 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3603

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D2 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase 1 binding NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphatase inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
 
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to morphine ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
dendrite development IEA
Inferred from Electronic Annotation
more info
 
developmental process involved in reproduction IEA
Inferred from Electronic Annotation
more info
 
filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
learning IEA
Inferred from Electronic Annotation
more info
 
male mating behavior IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein localization to actin cortical patch IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein localization to actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
protein localization to cell periphery IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth by extracellular stimulus TAS
Traceable Author Statement
more info
PubMed 
regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of exit from mitosis NAS
Non-traceable Author Statement
more info
PubMed 
regulation of opioid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
reproductive system development IEA
Inferred from Electronic Annotation
more info
 
response to L-phenylalanine derivative IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to clozapine IEA
Inferred from Electronic Annotation
more info
 
response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
response to kainic acid IEA
Inferred from Electronic Annotation
more info
 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
response to prostaglandin E IEA
Inferred from Electronic Annotation
more info
 
response to steroid hormone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of dendritic spine plasma membrane IEA
Inferred from Electronic Annotation
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine head IEA
Inferred from Electronic Annotation
more info
 
dendritic spine neck IEA
Inferred from Electronic Annotation
more info
 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 1 complex TAS
Traceable Author Statement
more info
PubMed 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neurabin-2
Names
neurabin-II
protein phosphatase 1, regulatory (inhibitor) subunit 9B
protein phosphatase 1, regulatory subunit 9B, spinophilin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034197.1 RefSeqGene

    Range
    4841..21781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032595.5NP_115984.3  neurabin-2

    See identical proteins and their annotated locations for NP_115984.3

    Status: REVIEWED

    Source sequence(s)
    ABBA01041227, AC002401, AJ401189, AL713642, BF448737, BM991997
    Consensus CDS
    CCDS74102.1
    UniProtKB/Swiss-Prot
    Q96SB3
    UniProtKB/TrEMBL
    D3DTX6
    Related
    ENSP00000478767.1, ENST00000612501.2
    Conserved Domains (3) summary
    smart00228
    Location:493582
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:649812
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:426489
    PDZ_5; PDZ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    50133737..50150677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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