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INSM2 INSM transcriptional repressor 2 [ Homo sapiens (human) ]

Gene ID: 84684, updated on 6-Sep-2022

Summary

Official Symbol
INSM2provided by HGNC
Official Full Name
INSM transcriptional repressor 2provided by HGNC
Primary source
HGNC:HGNC:17539
See related
Ensembl:ENSG00000168348 MIM:614027; AllianceGenome:HGNC:17539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IA6; IA-6; mlt1
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell cycle process. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See INSM2 in Genome Data Viewer
Location:
14q13.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (35534164..35537054)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (29721890..29724780)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (36003370..36006260)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984681 Neighboring gene uncharacterized LOC105370450 Neighboring gene keratin 18 pseudogene 6 Neighboring gene VISTA enhancer hs348 Neighboring gene Ral GTPase activating protein catalytic subunit alpha 1 Neighboring gene small nucleolar RNA SNORA31

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell cycle process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription repressor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
insulinoma-associated protein 2
Names
insulinoma-associated 2
insulinoma-associated protein IA-6
zinc finger protein IA-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032594.4NP_115983.3  insulinoma-associated protein 2

    See identical proteins and their annotated locations for NP_115983.3

    Status: VALIDATED

    Source sequence(s)
    AF260323, AL160231, BC130377
    Consensus CDS
    CCDS9657.1
    UniProtKB/Swiss-Prot
    Q96Q84, Q96T92
    Related
    ENSP00000306523.3, ENST00000307169.4
    Conserved Domains (3) summary
    sd00017
    Location:265285
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:426448
    zf-C2H2; Zinc finger, C2H2 type
    cl00873
    Location:140203
    PdxA; Pyridoxal phosphate biosynthetic protein PdxA

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    35534164..35537054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    29721890..29724780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)