Format

Send to:

Choose Destination

HINT2 histidine triad nucleotide binding protein 2 [ Homo sapiens (human) ]

Gene ID: 84681, updated on 5-Jan-2020

Summary

Official Symbol
HINT2provided by HGNC
Official Full Name
histidine triad nucleotide binding protein 2provided by HGNC
Primary source
HGNC:HGNC:18344
See related
Ensembl:ENSG00000137133 MIM:609997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIT-17
Summary
Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in kidney (RPKM 37.3), fat (RPKM 32.0) and 25 other tissues See more
Orthologs

Genomic context

See HINT2 in Genome Data Viewer
Location:
9p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35812960..35815479, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35812957..35815481, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RGP1 homolog, RAB6A GEF complex partner 1 Neighboring gene microseminoprotein, prostate associated Neighboring gene natriuretic peptide receptor 2 Neighboring gene sperm associated antigen 8 Neighboring gene family with sequence similarity 221 member B Neighboring gene transmembrane protein 8B Neighboring gene olfactory receptor family 13 subfamily E member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-lysine acetylation IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
histidine triad nucleotide-binding protein 2, mitochondrial
Names
HINT-2
HINT-3
HIT-17kDa
PKCI-1-related HIT protein
protein kinase C inhibitor-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032593.3NP_115982.1  histidine triad nucleotide-binding protein 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_115982.1

    Status: VALIDATED

    Source sequence(s)
    BC047737, BI759951, BM764627
    Consensus CDS
    CCDS6594.1
    UniProtKB/Swiss-Prot
    Q9BX68
    Related
    ENSP00000259667.5, ENST00000259667.6
    Conserved Domains (1) summary
    cd01276
    Location:53155
    PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35812960..35815479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447703.1XP_024303471.1  histidine triad nucleotide-binding protein 2, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00228
    Location:55135
    HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
  2. XM_024447702.1XP_024303470.1  histidine triad nucleotide-binding protein 2, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd01276
    Location:55157
    PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...
  3. XM_024447704.1XP_024303472.1  histidine triad nucleotide-binding protein 2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00228
    Location:53133
    HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
Support Center