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TRIM63 tripartite motif containing 63 [ Homo sapiens (human) ]

Gene ID: 84676, updated on 23-Nov-2021

Summary

Official Symbol
TRIM63provided by HGNC
Official Full Name
tripartite motif containing 63provided by HGNC
Primary source
HGNC:HGNC:16007
See related
Ensembl:ENSG00000158022 MIM:606131
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRF; SMRZ; MURF1; MURF2; RNF28
Summary
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
Expression
Biased expression in heart (RPKM 44.7) and esophagus (RPKM 2.8) See more
Orthologs
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Genomic context

See TRIM63 in Genome Data Viewer
Location:
1p36.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (26051301..26067630, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26377792..26394121, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 2 Neighboring gene uncharacterized LOC105376910 Neighboring gene Sharpr-MPRA regulatory region 4919 Neighboring gene VISTA enhancer hs2271 Neighboring gene PDLIM1 interacting kinase 1 like Neighboring gene uncharacterized LOC105376886 Neighboring gene Sharpr-MPRA regulatory region 12487

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32380

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables titin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in response to electrical stimulus involved in regulation of muscle adaptation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in skeletal muscle atrophy IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in M band IEA
Inferred from Electronic Annotation
more info
 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in microtubule NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM63
Names
RING-type E3 ubiquitin transferase TRIM63
iris ring finger protein
muscle specific ring finger protein 2
muscle-specific RING finger protein 1
ring finger protein 28
striated muscle RING zinc finger protein
tripartite motif containing 63, E3 ubiquitin protein ligase
tripartite motif-containing protein 63
NP_115977.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033268.1 RefSeqGene

    Range
    5001..21331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_757

mRNA and Protein(s)

  1. NM_032588.4NP_115977.2  E3 ubiquitin-protein ligase TRIM63

    See identical proteins and their annotated locations for NP_115977.2

    Status: REVIEWED

    Source sequence(s)
    AI351421, AL391650, BC080529, DA900348
    Consensus CDS
    CCDS273.1
    UniProtKB/Swiss-Prot
    Q969Q1
    Related
    ENSP00000363390.3, ENST00000374272.4
    Conserved Domains (3) summary
    smart00336
    Location:120159
    BBOX; B-Box-type zinc finger
    cd00162
    Location:2382
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:188283
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    26051301..26067630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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