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CARD6 caspase recruitment domain family member 6 [ Homo sapiens (human) ]

Gene ID: 84674, updated on 5-Aug-2018

Summary

Official Symbol
CARD6provided by HGNC
Official Full Name
caspase recruitment domain family member 6provided by HGNC
Primary source
HGNC:HGNC:16394
See related
Ensembl:ENSG00000132357 MIM:609986; Vega:OTTHUMG00000094775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CINCIN1
Summary
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in gall bladder (RPKM 6.9), spleen (RPKM 6.3) and 24 other tissues See more
Orthologs

Genomic context

See CARD6 in Genome Data Viewer
Location:
5p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (40841197..40855354)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (40841410..40855456)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506548 Neighboring gene small nucleolar RNA, C/D box 72 Neighboring gene ribosomal protein L37 Neighboring gene RNA, U7 small nuclear 161 pseudogene Neighboring gene complement C7 Neighboring gene maestro heat like repeat family member 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystem (from WikiPathways)
    Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
caspase recruitment domain-containing protein 6
Names
CARD-containing inhibitor of Nod1 and Cardiak-induced NF-kB activation
caspase recruitment domain protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032587.3NP_115976.2  caspase recruitment domain-containing protein 6

    See identical proteins and their annotated locations for NP_115976.2

    Status: REVIEWED

    Source sequence(s)
    AC026732, AF356193, BC093825
    Consensus CDS
    CCDS3935.1
    UniProtKB/Swiss-Prot
    Q9BX69
    Related
    ENSP00000254691.5, OTTHUMP00000120002, ENST00000254691.9, OTTHUMT00000211584
    Conserved Domains (2) summary
    pfam00619
    Location:992
    CARD; Caspase recruitment domain
    pfam11035
    Location:9611025
    SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    40841197..40855354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009989.1XP_016865478.1  caspase recruitment domain-containing protein 6 isoform X1

  2. XM_017009990.2XP_016865479.1  caspase recruitment domain-containing protein 6 isoform X2

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