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USP32 ubiquitin specific peptidase 32 [ Homo sapiens (human) ]

Gene ID: 84669, updated on 23-Nov-2021

Summary

Official Symbol
USP32provided by HGNC
Official Full Name
ubiquitin specific peptidase 32provided by HGNC
Primary source
HGNC:HGNC:19143
See related
Ensembl:ENSG00000170832 MIM:607740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USP10; NY-REN-60
Expression
Broad expression in testis (RPKM 36.8), brain (RPKM 14.5) and 23 other tissues See more
Orthologs
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Genomic context

See USP32 in Genome Data Viewer
Location:
17q23.1-q23.2
Exon count:
39
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (60177231..60422470, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (58254688..58469494, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996660 Neighboring gene carbonic anhydrase 4 Neighboring gene family with sequence similarity 106 member D, pseudogene Neighboring gene small Cajal body-specific RNA 20 Neighboring gene ribosomal protein L32 pseudogene 32 Neighboring gene septin 7 pseudogene 12 Neighboring gene H3 histone pseudogene 42 Neighboring gene uncharacterized LOC105371850 Neighboring gene chromosome 17 open reading frame 64 Neighboring gene ribosomal protein L12 pseudogene 38 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 42

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thiol-dependent deubiquitinase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiol-dependent deubiquitinase IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 32
Names
deubiquitinating enzyme 32
renal carcinoma antigen NY-REN-60
ubiquitin specific protease 32
ubiquitin thioesterase 32
ubiquitin thiolesterase 32
ubiquitin-specific-processing protease 32
NP_115971.2
XP_011523673.1
XP_011523674.1
XP_011523675.1
XP_011523676.1
XP_011523677.1
XP_011523678.1
XP_011523680.1
XP_011523681.1
XP_016880722.1
XP_016880723.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032582.4NP_115971.2  ubiquitin carboxyl-terminal hydrolase 32

    See identical proteins and their annotated locations for NP_115971.2

    Status: VALIDATED

    Source sequence(s)
    AC025048, AF533230, AL834444, BI459907
    Consensus CDS
    CCDS32697.1
    UniProtKB/Swiss-Prot
    Q8NFA0
    Related
    ENSP00000300896.3, ENST00000300896.9
    Conserved Domains (6) summary
    COG5560
    Location:5181316
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd00051
    Location:237293
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02553
    Location:12251565
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:519586
    DUSP; DUSP domain
    pfam13499
    Location:236293
    EF-hand_7; EF-hand domain pair
    pfam14836
    Location:623710
    Ubiquitin_3; Ubiquitin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    60177231..60422470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525372.1XP_011523674.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

    Conserved Domains (6) summary
    COG5560
    Location:5341332
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd00051
    Location:253309
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02553
    Location:12411581
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:535602
    DUSP; DUSP domain
    pfam13499
    Location:252309
    EF-hand_7; EF-hand domain pair
    pfam14836
    Location:639726
    Ubiquitin_3; Ubiquitin-like domain
  2. XM_011525371.1XP_011523673.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

    Conserved Domains (6) summary
    COG5560
    Location:5341346
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd00051
    Location:253309
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02553
    Location:12551595
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:535602
    DUSP; DUSP domain
    pfam13499
    Location:252309
    EF-hand_7; EF-hand domain pair
    pfam14836
    Location:653740
    Ubiquitin_3; Ubiquitin-like domain
  3. XM_011525376.1XP_011523678.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X6

    Conserved Domains (6) summary
    COG5560
    Location:5151313
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd00051
    Location:234290
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02553
    Location:12221562
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:516583
    DUSP; DUSP domain
    pfam13499
    Location:233290
    EF-hand_7; EF-hand domain pair
    pfam14836
    Location:620707
    Ubiquitin_3; Ubiquitin-like domain
  4. XM_011525374.1XP_011523676.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

    Conserved Domains (6) summary
    COG5560
    Location:5151327
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd00051
    Location:234290
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02553
    Location:12361576
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:516583
    DUSP; DUSP domain
    pfam13499
    Location:233290
    EF-hand_7; EF-hand domain pair
    pfam14836
    Location:634721
    Ubiquitin_3; Ubiquitin-like domain
  5. XM_011525373.1XP_011523675.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

    Conserved Domains (6) summary
    COG5560
    Location:5181330
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd00051
    Location:237293
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02553
    Location:12391579
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:519586
    DUSP; DUSP domain
    pfam13499
    Location:236293
    EF-hand_7; EF-hand domain pair
    pfam14836
    Location:637724
    Ubiquitin_3; Ubiquitin-like domain
  6. XM_011525375.1XP_011523677.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X5

    Conserved Domains (6) summary
    COG5560
    Location:5081320
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd00051
    Location:227283
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02553
    Location:12291569
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:509576
    DUSP; DUSP domain
    pfam13499
    Location:226283
    EF-hand_7; EF-hand domain pair
    pfam14836
    Location:627714
    Ubiquitin_3; Ubiquitin-like domain
  7. XM_017025233.1XP_016880722.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X8

  8. XM_011525378.1XP_011523680.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X7

    Conserved Domains (6) summary
    COG5560
    Location:4721284
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd00051
    Location:191247
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02553
    Location:11931533
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:473540
    DUSP; DUSP domain
    pfam13499
    Location:190247
    EF-hand_7; EF-hand domain pair
    pfam14836
    Location:591678
    Ubiquitin_3; Ubiquitin-like domain
  9. XM_011525379.3XP_011523681.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X9

    Conserved Domains (4) summary
    COG5560
    Location:2271039
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:9481288
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:228295
    DUSP; DUSP domain
    pfam14836
    Location:346433
    Ubiquitin_3; Ubiquitin-like domain
  10. XM_017025234.1XP_016880723.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X10

    Related
    ENSP00000467885.1, ENST00000592339.5
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