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RETNLB resistin like beta [ Homo sapiens (human) ]

Gene ID: 84666, updated on 27-Sep-2022

Summary

Official Symbol
RETNLBprovided by HGNC
Official Full Name
resistin like betaprovided by HGNC
Primary source
HGNC:HGNC:20388
See related
Ensembl:ENSG00000163515 MIM:605645; AllianceGenome:HGNC:20388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XCP2; FIZZ1; FIZZ2; HXCP2; RELMb; RELMbeta; RELM-beta
Summary
Predicted to enable hormone activity. Involved in epithelial cell proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon (RPKM 39.2), small intestine (RPKM 12.6) and 1 other tissue See more
Orthologs
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Genomic context

See RETNLB in Genome Data Viewer
Location:
3q13.13
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108755638..108757410, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111476011..111477791, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108474485..108476257, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374033 Neighboring gene uncharacterized LOC105374034 Neighboring gene T cell receptor associated transmembrane adaptor 1 Neighboring gene guanylate cyclase activator 1C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in epithelial cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
resistin-like beta
Names
C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 2
colon and small intestine-specific cysteine-rich protein
colon carcinoma-related gene protein
cysteine-rich secreted A12-alpha-like protein 1
cysteine-rich secreted protein A12-alpha-like 1
cysteine-rich secreted protein FIZZ2
found in inflammatory zone 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412183.1NP_001399112.1  resistin-like beta isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses the same exon combination as variant 1 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (2) uses a downstream in-frame start codon and has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    CP068275
  2. NM_032579.3NP_115968.1  resistin-like beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_115968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses the same exon combination as variant 2 but represents the allele encoded by the GRCh38 reference genome. The encoded isoform (1) has a longer N-terminus than isoform 2.
    Source sequence(s)
    AC092185, AY358655
    Consensus CDS
    CCDS2953.1
    UniProtKB/Swiss-Prot
    Q14D27, Q9BQ08
    Related
    ENSP00000295755.6, ENST00000295755.7
    Conserved Domains (1) summary
    pfam06954
    Location:23110
    Resistin; Resistin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    108755638..108757410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    111476011..111477791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)