Format

Send to:

Choose Destination

DPY30 dpy-30 histone methyltransferase complex regulatory subunit [ Homo sapiens (human) ]

Gene ID: 84661, updated on 7-Jun-2020

Summary

Official Symbol
DPY30provided by HGNC
Official Full Name
dpy-30 histone methyltransferase complex regulatory subunitprovided by HGNC
Primary source
HGNC:HGNC:24590
See related
Ensembl:ENSG00000162961 MIM:612032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cps25; Saf19; HDPY-30
Summary
This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in thyroid (RPKM 7.5), adrenal (RPKM 7.3) and 25 other tissues See more
Orthologs

Genomic context

See DPY30 in Genome Data Viewer
Location:
2p22.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (32011649..32039840, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32245856..32264890, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene adenylate kinase 2 pseudogene 2 Neighboring gene mediator of cell motility 1 Neighboring gene spastin Neighboring gene solute carrier family 30 member 6 Neighboring gene DEAD-box helicase 50 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromatin silencing at telomere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K4 methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H3-K4 methylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
MLL3/4 complex IDA
Inferred from Direct Assay
more info
PubMed 
Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Set1C/COMPASS complex IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein dpy-30 homolog
Names
dpy-30 homolog
dpy-30-like protein
dpy-30L

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321209.2NP_001308138.1  protein dpy-30 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    BC015970, BM505380, BQ276899
    Consensus CDS
    CCDS1777.1
    UniProtKB/Swiss-Prot
    Q9C005
    Related
    ENSP00000345837.5, ENST00000342166.10
    Conserved Domains (1) summary
    pfam05186
    Location:5293
    Dpy-30; Dpy-30 motif
  2. NM_001321210.2NP_001308139.1  protein dpy-30 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL121655, BG187724, BG940527, BQ276899
    Conserved Domains (1) summary
    pfam05186
    Location:5276
    Dpy-30; Dpy-30 motif
  3. NM_032574.3NP_115963.1  protein dpy-30 homolog isoform 1

    See identical proteins and their annotated locations for NP_115963.1

    Status: VALIDATED

    Source sequence(s)
    AF226998, AL121655, BM505380, BQ276899
    Consensus CDS
    CCDS1777.1
    UniProtKB/Swiss-Prot
    Q9C005
    Related
    ENSP00000295066.3, ENST00000295066.3
    Conserved Domains (1) summary
    pfam05186
    Location:5293
    Dpy-30; Dpy-30 motif

RNA

  1. NR_135585.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121655, AV725116, BM505380, BQ276899
  2. NR_135587.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA442557, AL121655, BC015970, BM505380, BQ276899

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    32011649..32039840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005111.1XP_016860600.1  protein dpy-30 homolog isoform X1

    UniProtKB/TrEMBL
    B4DIS3
    Conserved Domains (1) summary
    pfam05186
    Location:5276
    Dpy-30; Dpy-30 motif
  2. XM_006712118.3XP_006712181.1  protein dpy-30 homolog isoform X1

    See identical proteins and their annotated locations for XP_006712181.1

    UniProtKB/TrEMBL
    B4DIS3
    Conserved Domains (1) summary
    pfam05186
    Location:5276
    Dpy-30; Dpy-30 motif
  3. XM_011533133.2XP_011531435.1  protein dpy-30 homolog isoform X1

    See identical proteins and their annotated locations for XP_011531435.1

    UniProtKB/TrEMBL
    B4DIS3
    Conserved Domains (1) summary
    pfam05186
    Location:5276
    Dpy-30; Dpy-30 motif
  4. XM_006712117.4XP_006712180.1  protein dpy-30 homolog isoform X2

    See identical proteins and their annotated locations for XP_006712180.1

    UniProtKB/TrEMBL
    B4DIS3
    Conserved Domains (1) summary
    pfam05186
    Location:5276
    Dpy-30; Dpy-30 motif
Support Center