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RNASE7 ribonuclease A family member 7 [ Homo sapiens (human) ]

Gene ID: 84659, updated on 23-Nov-2021

Summary

Official Symbol
RNASE7provided by HGNC
Official Full Name
ribonuclease A family member 7provided by HGNC
Primary source
HGNC:HGNC:19278
See related
Ensembl:ENSG00000165799 MIM:612484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAE1
Summary
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Expression
Biased expression in esophagus (RPKM 35.9), skin (RPKM 11.5) and 1 other tissue See more
Orthologs
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Genomic context

See RNASE7 in Genome Data Viewer
Location:
14q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (21042362..21044233)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21510521..21512392)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NDRG family member 2 Neighboring gene microRNA 6717 Neighboring gene tubulin polymerization promoting protein family member 2 Neighboring gene ribonuclease A family member 13 (inactive) Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133220

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribonuclease 7
Names
RNase 7
SAP-2
ribonuclease, RNase A family, 7
skin-derived antimicrobial protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032572.4NP_115961.3  ribonuclease 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS41914.1
    Related
    ENSP00000298690.3, ENST00000298690.5
    Conserved Domains (1) summary
    pfam00074
    Location:35153
    RnaseA; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    21042362..21044233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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