U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GLYR1 glyoxylate reductase 1 homolog [ Homo sapiens (human) ]

Gene ID: 84656, updated on 5-Jul-2025
Official Symbol
GLYR1provided by HGNC
Official Full Name
glyoxylate reductase 1 homologprovided by HGNC
Primary source
HGNC:HGNC:24434
See related
Ensembl:ENSG00000140632 MIM:610660; AllianceGenome:HGNC:24434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NP60; NPAC; hNDF; BM045; HIBDL; N-PAC
Summary
Enables several functions, including chromatin-protein adaptor activity; histone binding activity; and nucleosome binding activity. Involved in transcription elongation-coupled chromatin remodeling and transcription initiation-coupled chromatin remodeling. Located in cytosol and nucleoplasm. Part of nucleosome. Is active in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in kidney (RPKM 24.0), brain (RPKM 23.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See GLYR1 in Genome Data Viewer
Location:
16p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4803203..4847288, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4832757..4876778, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4853204..4897289, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene septin 12 Neighboring gene small integral membrane protein 22 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4852142-4852642 Neighboring gene Sharpr-MPRA regulatory region 4562 Neighboring gene rogdi atypical leucine zipper Neighboring gene uncharacterized LOC124903638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4897448-4898290 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:4901871-4903070 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:4908973-4910172 Neighboring gene ubinuclein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:4920799-4920984 Neighboring gene MPRA-validated peak2474 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4935135-4935635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4945259-4946104 Neighboring gene uncharacterized LOC124903637 Neighboring gene periplakin

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin-protein adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytokine-like nuclear factor N-PAC
Names
3-hydroxyisobutyrate dehydrogenase-like protein
cytokine-like nuclear factor n-pac
nuclear protein 60 kDa
nuclear protein 60kDa
nuclear protein NP60
nuclear protein of 60 kDa
nucleosome-destabilizing factor
putative oxidoreductase GLYR1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308096.2NP_001295025.1  cytokine-like nuclear factor N-PAC isoform 2

    See identical proteins and their annotated locations for NP_001295025.1

    Status: VALIDATED

    Source sequence(s)
    AC020663, AF217521, AF326966, HY130375
    Consensus CDS
    CCDS81945.1
    UniProtKB/TrEMBL
    K7EMM8
    Related
    ENSP00000468328.1, ENST00000591451.5
    Conserved Domains (3) summary
    cd05836
    Location:690
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:268545
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    pfam15376
    Location:110173
    DUF4603; Domain of unknown function (DUF4603)
  2. NM_001324096.2NP_001311025.2  cytokine-like nuclear factor N-PAC isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC020663, KF456151
    UniProtKB/TrEMBL
    K7EMM8
    Conserved Domains (2) summary
    cd05836
    Location:690
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:187464
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
  3. NM_001324097.2NP_001311026.2  cytokine-like nuclear factor N-PAC isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC020663, AK296842
    Consensus CDS
    CCDS92098.1
    UniProtKB/TrEMBL
    K7EMM8
    Related
    ENSP00000390276.4, ENST00000436648.9
    Conserved Domains (3) summary
    cd05836
    Location:690
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:187470
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    cl21454
    Location:129221
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001324098.2NP_001311027.2  cytokine-like nuclear factor N-PAC isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC020663, KF456151
    UniProtKB/TrEMBL
    K7EMM8
    Related
    ENSP00000466570.1, ENST00000589389.5
    Conserved Domains (3) summary
    cd05836
    Location:690
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:251534
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    pfam15376
    Location:110173
    DUF4603; Domain of unknown function (DUF4603)
  5. NM_032569.4NP_115958.2  cytokine-like nuclear factor N-PAC isoform 1

    See identical proteins and their annotated locations for NP_115958.2

    Status: VALIDATED

    Source sequence(s)
    AF244907, CB529066, CK430984, CR933687, DB492328
    Consensus CDS
    CCDS10524.1
    UniProtKB/Swiss-Prot
    B4DL47, C9JJ40, C9JJ60, Q49A26, Q5U632, Q6P1Q2, Q6V3W7, Q9BTI1, Q9BXK2
    UniProtKB/TrEMBL
    K7EMM8
    Related
    ENSP00000322716.6, ENST00000321919.14
    Conserved Domains (4) summary
    cd05836
    Location:690
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:268551
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    pfam15376
    Location:110173
    DUF4603; Domain of unknown function (DUF4603)
    cl21454
    Location:210302
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_136695.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020663, BC047223, BC064940
    Related
    ENST00000588732.5
  2. NR_136696.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020663, KF456151
  3. NR_136697.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020663, KF456151
  4. NR_136698.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020663, KF456151
  5. NR_136699.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020663, KF456151
  6. NR_136700.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020663, KF456151

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    4803203..4847288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    4832757..4876778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)