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SPZ1 spermatogenic leucine zipper 1 [ Homo sapiens (human) ]

Gene ID: 84654, updated on 23-Nov-2021

Summary

Official Symbol
SPZ1provided by HGNC
Official Full Name
spermatogenic leucine zipper 1provided by HGNC
Primary source
HGNC:HGNC:30721
See related
Ensembl:ENSG00000164299 MIM:618068
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CILD38; NYD-TSP1; PPP1R148
Summary
This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments. [provided by RefSeq, Oct 2011]
Orthologs
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Genomic context

See SPZ1 in Genome Data Viewer
Location:
5q14.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (80320002..80321842)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (79615821..79617661)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene actin beta pseudogene Neighboring gene ribosomal protein L39 pseudogene 20 Neighboring gene RBMX2 pseudogene 5 Neighboring gene mediator complex subunit 27 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25709

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
spermatogenic leucine zipper protein 1
Names
protein phosphatase 1, regulatory subunit 148
spermatogenic zip 1
testis secretory sperm-binding protein Li 232m
testis-specific protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030332.1 RefSeqGene

    Range
    5032..6872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032567.4NP_115956.3  spermatogenic leucine zipper protein 1

    See identical proteins and their annotated locations for NP_115956.3

    Status: REVIEWED

    Source sequence(s)
    AI138399, BC033798, BG723698, BU853967
    Consensus CDS
    CCDS43336.1
    UniProtKB/Swiss-Prot
    Q9BXG8
    UniProtKB/TrEMBL
    A0A140VKA5
    Related
    ENSP00000369611.3, ENST00000296739.6
    Conserved Domains (1) summary
    TIGR02168
    Location:63340
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    80320002..80321842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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