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DGAT2 diacylglycerol O-acyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 84649, updated on 4-May-2020

Summary

Official Symbol
DGAT2provided by HGNC
Official Full Name
diacylglycerol O-acyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:16940
See related
Ensembl:ENSG00000062282 MIM:606983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARAT; HMFN1045; GS1999FULL
Summary
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Biased expression in fat (RPKM 381.0), liver (RPKM 87.8) and 1 other tissue See more
Orthologs

Genomic context

See DGAT2 in Genome Data Viewer
Location:
11q13.5
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (75768733..75801536)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (75479778..75512581)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 786, pseudogene Neighboring gene uncharacterized LOC283214 Neighboring gene UVRAG divergent transcript Neighboring gene UV radiation resistance associated Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 1A pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686A15125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2-acylglycerol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol O-acyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
retinol O-fatty-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
cellular response to oleic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fat pad development ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
long-chain fatty-acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of fatty acid oxidation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of plasma lipoprotein particle levels ISS
Inferred from Sequence or Structural Similarity
more info
 
retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
triglyceride biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IC
Inferred by Curator
more info
PubMed 
integral component of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
diacylglycerol O-acyltransferase 2
Names
acyl-CoA retinol O-fatty-acyltransferase
diacylglycerol O-acyltransferase homolog 2
diacylglycerol O-acyltransferase-like protein 2
diglyceride acyltransferase 2
NP_001240820.1
NP_115953.2
XP_011543606.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046775.1 RefSeqGene

    Range
    5046..37802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001253891.1NP_001240820.1  diacylglycerol O-acyltransferase 2 isoform 2

    See identical proteins and their annotated locations for NP_001240820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AI126704, AP001922, AP003031, AY780647
    Consensus CDS
    CCDS58162.1
    UniProtKB/Swiss-Prot
    Q96PD7
    Related
    ENSP00000365438.3, ENST00000376262.7
    Conserved Domains (1) summary
    pfam03982
    Location:49345
    DAGAT; Diacylglycerol acyltransferase
  2. NM_032564.5NP_115953.2  diacylglycerol O-acyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_115953.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL834287, DB462004
    Consensus CDS
    CCDS31642.1
    UniProtKB/Swiss-Prot
    Q96PD7
    Related
    ENSP00000228027.6, ENST00000228027.12
    Conserved Domains (1) summary
    pfam03982
    Location:92388
    DAGAT; Diacylglycerol acyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    75768733..75801536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545304.2XP_011543606.1  diacylglycerol O-acyltransferase 2 isoform X1

    Conserved Domains (1) summary
    pfam03982
    Location:62358
    DAGAT; Diacylglycerol acyltransferase
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