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PLA2G12B phospholipase A2 group XIIB [ Homo sapiens (human) ]

Gene ID: 84647, updated on 5-Aug-2018

Summary

Official Symbol
PLA2G12Bprovided by HGNC
Official Full Name
phospholipase A2 group XIIBprovided by HGNC
Primary source
HGNC:HGNC:18555
See related
Ensembl:ENSG00000138308 MIM:611653; Vega:OTTHUMG00000018446
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GXIIB; FKSG71; PLA2G13; GXIIIsPLA2; sPLA2-GXIIB
Summary
The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Biased expression in liver (RPKM 15.3), small intestine (RPKM 14.6) and 5 other tissues See more
Orthologs

Genomic context

See PLA2G12B in Genome Data Viewer
Location:
10q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (72934762..72955044, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (74694519..74714590, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uniporter Neighboring gene microRNA 4676 Neighboring gene oncoprotein induced transcript 3 Neighboring gene nucleophosmin 1 pseudogene 24 Neighboring gene ribosomal protein L17 pseudogene 50 Neighboring gene prolyl 4-hydroxylase subunit alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138151

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
group XIIB secretory phospholipase A2-like protein
Names
group XIII secreted phospholipase A2
phospholipase A2, group XIII
NP_001305053.1
NP_001305054.1
NP_115951.2
XP_005270301.1
XP_024304003.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318124.1NP_001305053.1  group XIIB secretory phospholipase A2-like protein isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
    Source sequence(s)
    AK311349, BC143532, BP274516, DA536331
    UniProtKB/Swiss-Prot
    Q9BX93
    Conserved Domains (1) summary
    pfam06951
    Location:12194
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)
  2. NM_001318125.1NP_001305054.1  group XIIB secretory phospholipase A2-like protein isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK311349, BP274516
    Conserved Domains (1) summary
    pfam06951
    Location:11105
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)
  3. NM_032562.4NP_115951.2  group XIIB secretory phospholipase A2-like protein isoform a precursor

    See identical proteins and their annotated locations for NP_115951.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK311349, AY358032, BP274516, DA536331
    Consensus CDS
    CCDS7319.1
    UniProtKB/Swiss-Prot
    Q9BX93
    Related
    ENSP00000362123.3, OTTHUMP00000019792, ENST00000373032.3, OTTHUMT00000048598
    Conserved Domains (1) summary
    pfam06951
    Location:12195
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    72934762..72955044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270244.4XP_005270301.1  group XIIB secretory phospholipase A2-like protein isoform X1

    See identical proteins and their annotated locations for XP_005270301.1

    Conserved Domains (1) summary
    pfam06951
    Location:12191
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)
  2. XM_024448235.1XP_024304003.1  group XIIB secretory phospholipase A2-like protein isoform X2

    Conserved Domains (1) summary
    pfam06951
    Location:12190
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)
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