U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KIF2B kinesin family member 2B [ Homo sapiens (human) ]

Gene ID: 84643, updated on 5-Aug-2022

Summary

Official Symbol
KIF2Bprovided by HGNC
Official Full Name
kinesin family member 2Bprovided by HGNC
Primary source
HGNC:HGNC:29443
See related
Ensembl:ENSG00000141200 MIM:615142; AllianceGenome:HGNC:29443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable microtubule binding activity and microtubule motor activity. Involved in metaphase plate congression; microtubule depolymerization; and regulation of chromosome segregation. Located in intercellular bridge; mitotic spindle; and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KIF2B in Genome Data Viewer
Location:
17q22
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (53822927..53825193)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (54698157..54700426)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (51900288..51902554)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 48 Neighboring gene uncharacterized LOC124904030 Neighboring gene zinc finger protein 816A pseudogene Neighboring gene uncharacterized LOC107985001

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of kinesin family member 2B (KIF2B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ53902

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule depolymerization TAS
Traceable Author Statement
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF2B
Names
kinesin protein
testis tissue sperm-binding protein Li 82P

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032559.5NP_115948.4  kinesin-like protein KIF2B

    See identical proteins and their annotated locations for NP_115948.4

    Status: VALIDATED

    Source sequence(s)
    AC019315, AF333335
    Consensus CDS
    CCDS32685.1
    UniProtKB/Swiss-Prot
    Q8N4N8, Q9BXG6
    UniProtKB/TrEMBL
    A0A140VKG5
    Related
    ENSP00000268919.4, ENST00000268919.6
    Conserved Domains (2) summary
    cd01367
    Location:213541
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:219541
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    53822927..53825193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    54698157..54700426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)