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GPR174 G protein-coupled receptor 174 [ Homo sapiens (human) ]

Gene ID: 84636, updated on 23-Nov-2021

Summary

Official Symbol
GPR174provided by HGNC
Official Full Name
G protein-coupled receptor 174provided by HGNC
Primary source
HGNC:HGNC:30245
See related
Ensembl:ENSG00000147138 MIM:300903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKSG79; GPCR17; LYPSR3
Summary
This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]
Orthologs
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Genomic context

See GPR174 in Genome Data Viewer
Location:
Xq21.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (79144688..79175318)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (78400185..78430815)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene P2Y receptor family member 10 Neighboring gene P2Y receptor family member 10B, pseudogene Neighboring gene collagen triple helix repeat containing 1 pseudogene 1 Neighboring gene kinesin family member 4C, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
GeneReviews: Not available

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bioactive lipid receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable G-protein coupled receptor 174

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016565.2 RefSeqGene

    Range
    5001..9347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032553.3NP_115942.1  probable G-protein coupled receptor 174

    See identical proteins and their annotated locations for NP_115942.1

    Status: VALIDATED

    Source sequence(s)
    AL590222
    Consensus CDS
    CCDS14443.1
    UniProtKB/Swiss-Prot
    Q9BXC1
    Related
    ENSP00000494310.1, ENST00000645147.2
    Conserved Domains (1) summary
    pfam00001
    Location:36292
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    79144688..79175318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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