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TEAD2 TEA domain transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 8463, updated on 23-Sep-2022

Summary

Official Symbol
TEAD2provided by HGNC
Official Full Name
TEA domain transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:11715
See related
Ensembl:ENSG00000074219 MIM:601729; AllianceGenome:HGNC:11715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETF; TEF4; TEF-4; TEAD-2
Summary
Enables several functions, including DNA-binding transcription factor activity; disordered domain specific binding activity; and transcription coactivator binding activity. Involved in hippo signaling; positive regulation of transcription, DNA-templated; and protein-containing complex assembly. Located in cytosol and nucleoplasm. Part of TEAD-YAP complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 17.4), ovary (RPKM 10.9) and 24 other tissues See more
Orthologs
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Genomic context

See TEAD2 in Genome Data Viewer
Location:
19q13.33
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49340595..49362416, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52338023..52359872, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49843852..49865673, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SUMO1 pseudogene 4 Neighboring gene solute carrier family 6 member 16 Neighboring gene microRNA 4324 Neighboring gene CD37 molecule Neighboring gene uncharacterized LOC101928295 Neighboring gene dickkopf like acrosomal protein 1 Neighboring gene KASH domain containing 5 Neighboring gene uncharacterized LOC124904740

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic heart tube morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lateral mesoderm development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
 
involved_in notochord development IEA
Inferred from Electronic Annotation
more info
 
involved_in paraxial mesoderm development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of TEAD-YAP complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcriptional enhancer factor TEF-4
Names
TEA domain family member 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256658.2NP_001243587.1  transcriptional enhancer factor TEF-4 isoform 1

    See identical proteins and their annotated locations for NP_001243587.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC007556, BC051301, BG334109
    Consensus CDS
    CCDS58671.1
    UniProtKB/Swiss-Prot
    Q15562
    UniProtKB/TrEMBL
    A0A024QZE2
    Related
    ENSP00000469672.1, ENST00000601519.5
    Conserved Domains (2) summary
    smart00426
    Location:40107
    TEA; TEA domain
    pfam17725
    Location:229447
    YBD; YAP binding domain
  2. NM_001256659.2NP_001243588.1  transcriptional enhancer factor TEF-4 isoform 1

    See identical proteins and their annotated locations for NP_001243588.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK290736, BC007556
    Consensus CDS
    CCDS58671.1
    UniProtKB/Swiss-Prot
    Q15562
    UniProtKB/TrEMBL
    A0A024QZE2
    Related
    ENSP00000366419.4, ENST00000377214.8
    Conserved Domains (2) summary
    smart00426
    Location:40107
    TEA; TEA domain
    pfam17725
    Location:229447
    YBD; YAP binding domain
  3. NM_001256660.2NP_001243589.1  transcriptional enhancer factor TEF-4 isoform 2

    See identical proteins and their annotated locations for NP_001243589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is longer than isoform 1.
    Source sequence(s)
    AL832240, BC007556, BG334109
    Consensus CDS
    CCDS59406.1
    UniProtKB/Swiss-Prot
    Q15562
    Related
    ENSP00000469640.2, ENST00000593945.6
    Conserved Domains (2) summary
    smart00426
    Location:40107
    TEA; TEA domain
    pfam17725
    Location:230448
    YBD; YAP binding domain
  4. NM_001256661.2NP_001243590.1  transcriptional enhancer factor TEF-4 isoform 2

    See identical proteins and their annotated locations for NP_001243590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is longer than isoform 1.
    Source sequence(s)
    AC010524, BC007556, BC018803
    Consensus CDS
    CCDS59406.1
    UniProtKB/Swiss-Prot
    Q15562
    Related
    ENSP00000472109.1, ENST00000598810.5
    Conserved Domains (2) summary
    smart00426
    Location:40107
    TEA; TEA domain
    pfam17725
    Location:230448
    YBD; YAP binding domain
  5. NM_001256662.2NP_001243591.1  transcriptional enhancer factor TEF-4 isoform 4

    See identical proteins and their annotated locations for NP_001243591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, including the use of a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK300241, BC007556
    Consensus CDS
    CCDS58670.1
    UniProtKB/Swiss-Prot
    Q15562
    Related
    ENSP00000437928.1, ENST00000539846.5
  6. NM_003598.2NP_003589.1  transcriptional enhancer factor TEF-4 isoform 3

    See identical proteins and their annotated locations for NP_003589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    BC007556
    Consensus CDS
    CCDS12761.1
    UniProtKB/Swiss-Prot
    Q15562, Q96IG3
    Related
    ENSP00000310701.1, ENST00000311227.6
    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49340595..49362416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439541.1XP_047295497.1  transcriptional enhancer factor TEF-4 isoform X9

  2. XM_047439538.1XP_047295494.1  transcriptional enhancer factor TEF-4 isoform X8

  3. XM_047439537.1XP_047295493.1  transcriptional enhancer factor TEF-4 isoform X7

  4. XM_047439535.1XP_047295491.1  transcriptional enhancer factor TEF-4 isoform X6

  5. XM_047439523.1XP_047295479.1  transcriptional enhancer factor TEF-4 isoform X2

  6. XM_011527404.3XP_011525706.1  transcriptional enhancer factor TEF-4 isoform X5

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  7. XM_011527399.3XP_011525701.1  transcriptional enhancer factor TEF-4 isoform X1

    See identical proteins and their annotated locations for XP_011525701.1

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  8. XM_047439544.1XP_047295500.1  transcriptional enhancer factor TEF-4 isoform X10

  9. XM_047439543.1XP_047295499.1  transcriptional enhancer factor TEF-4 isoform X9

  10. XM_047439539.1XP_047295495.1  transcriptional enhancer factor TEF-4 isoform X8

  11. XM_047439528.1XP_047295484.1  transcriptional enhancer factor TEF-4 isoform X4

    UniProtKB/Swiss-Prot
    Q96IG3
  12. XM_011527403.2XP_011525705.1  transcriptional enhancer factor TEF-4 isoform X3

    See identical proteins and their annotated locations for XP_011525705.1

    UniProtKB/Swiss-Prot
    Q15562
    UniProtKB/TrEMBL
    A0A024QZE2
    Conserved Domains (2) summary
    smart00426
    Location:40107
    TEA; TEA domain
    pfam17725
    Location:229447
    YBD; YAP binding domain
  13. XM_011527400.3XP_011525702.1  transcriptional enhancer factor TEF-4 isoform X1

    See identical proteins and their annotated locations for XP_011525702.1

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  14. XM_047439532.1XP_047295488.1  transcriptional enhancer factor TEF-4 isoform X4

    UniProtKB/Swiss-Prot
    Q96IG3
  15. XM_047439522.1XP_047295478.1  transcriptional enhancer factor TEF-4 isoform X1

  16. XM_047439542.1XP_047295498.1  transcriptional enhancer factor TEF-4 isoform X9

  17. XM_047439540.1XP_047295496.1  transcriptional enhancer factor TEF-4 isoform X8

  18. XM_047439531.1XP_047295487.1  transcriptional enhancer factor TEF-4 isoform X4

    UniProtKB/Swiss-Prot
    Q96IG3
  19. XM_047439526.1XP_047295482.1  transcriptional enhancer factor TEF-4 isoform X3

    UniProtKB/TrEMBL
    A0A024QZE2
  20. XM_011527402.2XP_011525704.1  transcriptional enhancer factor TEF-4 isoform X1

    See identical proteins and their annotated locations for XP_011525704.1

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  21. XM_047439530.1XP_047295486.1  transcriptional enhancer factor TEF-4 isoform X4

    UniProtKB/Swiss-Prot
    Q96IG3
  22. XM_047439527.1XP_047295483.1  transcriptional enhancer factor TEF-4 isoform X3

    UniProtKB/TrEMBL
    A0A024QZE2
  23. XM_047439533.1XP_047295489.1  transcriptional enhancer factor TEF-4 isoform X5

  24. XM_047439521.1XP_047295477.1  transcriptional enhancer factor TEF-4 isoform X1

  25. XM_047439529.1XP_047295485.1  transcriptional enhancer factor TEF-4 isoform X4

    UniProtKB/Swiss-Prot
    Q96IG3
  26. XM_047439525.1XP_047295481.1  transcriptional enhancer factor TEF-4 isoform X3

    UniProtKB/TrEMBL
    A0A024QZE2
  27. XM_047439524.1XP_047295480.1  transcriptional enhancer factor TEF-4 isoform X2

  28. XM_005259334.5XP_005259391.1  transcriptional enhancer factor TEF-4 isoform X9

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  29. XM_006723428.4XP_006723491.1  transcriptional enhancer factor TEF-4 isoform X8

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  30. XM_047439536.1XP_047295492.1  transcriptional enhancer factor TEF-4 isoform X7

  31. XM_047439534.1XP_047295490.1  transcriptional enhancer factor TEF-4 isoform X6

  32. XM_047439520.1XP_047295476.1  transcriptional enhancer factor TEF-4 isoform X1

  33. XM_011527401.1XP_011525703.1  transcriptional enhancer factor TEF-4 isoform X1

    See identical proteins and their annotated locations for XP_011525703.1

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  34. XM_006723429.2XP_006723492.1  transcriptional enhancer factor TEF-4 isoform X11

  35. XM_011527406.4XP_011525708.1  transcriptional enhancer factor TEF-4 isoform X13

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  36. XM_011527405.4XP_011525707.1  transcriptional enhancer factor TEF-4 isoform X12

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52338023..52359872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)