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TEAD2 TEA domain transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 8463, updated on 29-Mar-2020

Summary

Official Symbol
TEAD2provided by HGNC
Official Full Name
TEA domain transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:11715
See related
Ensembl:ENSG00000074219 MIM:601729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETF; TEF4; TEF-4; TEAD-2
Expression
Ubiquitous expression in endometrium (RPKM 17.4), ovary (RPKM 10.9) and 24 other tissues See more
Orthologs

Genomic context

See TEAD2 in Genome Data Viewer
Location:
19q13.33
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49340595..49362452, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49843852..49865714, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SUMO1 pseudogene 4 Neighboring gene solute carrier family 6 member 16 Neighboring gene microRNA 4324 Neighboring gene CD37 molecule Neighboring gene uncharacterized LOC101928295 Neighboring gene dickkopf like acrosomal protein 1 Neighboring gene KASH domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
disordered domain specific binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
embryonic heart tube morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
lateral mesoderm development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
notochord development IEA
Inferred from Electronic Annotation
more info
 
paraxial mesoderm development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
TEAD-2-YAP complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcriptional enhancer factor TEF-4
Names
TEA domain family member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256658.2NP_001243587.1  transcriptional enhancer factor TEF-4 isoform 1

    See identical proteins and their annotated locations for NP_001243587.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC007556, BC051301, BG334109
    Consensus CDS
    CCDS58671.1
    UniProtKB/Swiss-Prot
    Q15562
    UniProtKB/TrEMBL
    A0A024QZE2
    Related
    ENSP00000469672.1, ENST00000601519.5
    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  2. NM_001256659.2NP_001243588.1  transcriptional enhancer factor TEF-4 isoform 1

    See identical proteins and their annotated locations for NP_001243588.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK290736, BC007556
    Consensus CDS
    CCDS58671.1
    UniProtKB/Swiss-Prot
    Q15562
    UniProtKB/TrEMBL
    A0A024QZE2
    Related
    ENSP00000366419.4, ENST00000377214.8
    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  3. NM_001256660.2NP_001243589.1  transcriptional enhancer factor TEF-4 isoform 2

    See identical proteins and their annotated locations for NP_001243589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is longer than isoform 1.
    Source sequence(s)
    AL832240, BC007556, BG334109
    Consensus CDS
    CCDS59406.1
    UniProtKB/Swiss-Prot
    Q15562
    Related
    ENSP00000469640.1, ENST00000593945.5
    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  4. NM_001256661.2NP_001243590.1  transcriptional enhancer factor TEF-4 isoform 2

    See identical proteins and their annotated locations for NP_001243590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is longer than isoform 1.
    Source sequence(s)
    AC010524, BC007556, BC018803
    Consensus CDS
    CCDS59406.1
    UniProtKB/Swiss-Prot
    Q15562
    Related
    ENSP00000472109.1, ENST00000598810.5
    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  5. NM_001256662.2NP_001243591.1  transcriptional enhancer factor TEF-4 isoform 4

    See identical proteins and their annotated locations for NP_001243591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, including the use of a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK300241, BC007556
    Consensus CDS
    CCDS58670.1
    UniProtKB/Swiss-Prot
    Q15562
    Related
    ENSP00000437928.1, ENST00000539846.5
  6. NM_003598.2NP_003589.1  transcriptional enhancer factor TEF-4 isoform 3

    See identical proteins and their annotated locations for NP_003589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    BC007556
    Consensus CDS
    CCDS12761.1
    UniProtKB/Swiss-Prot
    Q15562
    Related
    ENSP00000310701.1, ENST00000311227.6
    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49340595..49362452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527399.2XP_011525701.1  transcriptional enhancer factor TEF-4 isoform X1

    See identical proteins and their annotated locations for XP_011525701.1

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  2. XM_011527403.1XP_011525705.1  transcriptional enhancer factor TEF-4 isoform X2

    See identical proteins and their annotated locations for XP_011525705.1

    UniProtKB/Swiss-Prot
    Q15562
    UniProtKB/TrEMBL
    A0A024QZE2
    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  3. XM_011527400.2XP_011525702.1  transcriptional enhancer factor TEF-4 isoform X1

    See identical proteins and their annotated locations for XP_011525702.1

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  4. XM_011527402.2XP_011525704.1  transcriptional enhancer factor TEF-4 isoform X1

    See identical proteins and their annotated locations for XP_011525704.1

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  5. XM_011527404.2XP_011525706.1  transcriptional enhancer factor TEF-4 isoform X3

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  6. XM_005259334.4XP_005259391.1  transcriptional enhancer factor TEF-4 isoform X5

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  7. XM_006723428.3XP_006723491.1  transcriptional enhancer factor TEF-4 isoform X4

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  8. XM_011527401.1XP_011525703.1  transcriptional enhancer factor TEF-4 isoform X1

    See identical proteins and their annotated locations for XP_011525703.1

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  9. XM_006723429.2XP_006723492.1  transcriptional enhancer factor TEF-4 isoform X6

  10. XM_011527405.3XP_011525707.1  transcriptional enhancer factor TEF-4 isoform X7

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
  11. XM_011527406.3XP_011525708.1  transcriptional enhancer factor TEF-4 isoform X8

    Conserved Domains (1) summary
    smart00426
    Location:40107
    TEA; TEA domain
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