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TNRC18 trinucleotide repeat containing 18 [ Homo sapiens (human) ]

Gene ID: 84629, updated on 23-Sep-2022

Summary

Official Symbol
TNRC18provided by HGNC
Official Full Name
trinucleotide repeat containing 18provided by HGNC
Primary source
HGNC:HGNC:11962
See related
Ensembl:ENSG00000182095 AllianceGenome:HGNC:11962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAGL79; TNRC18A
Summary
Predicted to enable chromatin binding activity. Located in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 6.4), colon (RPKM 6.2) and 25 other tissues See more
Orthologs
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Genomic context

See TNRC18 in Genome Data Viewer
Location:
7p22.1
Exon count:
36
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (5306811..5423834, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (5424509..5541506, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5346442..5463465, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9837 Neighboring gene Sharpr-MPRA regulatory region 3727 Neighboring gene solute carrier family 29 member 4 Neighboring gene long intergenic non-protein coding RNA 2983 Neighboring gene F-box and leucine rich repeat protein 18 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1856

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
trinucleotide repeat-containing gene 18 protein
Names
long CAG trinucleotide repeat-containing gene 79 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034123.1 RefSeqGene

    Range
    4713..121736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080495.3NP_001073964.2  trinucleotide repeat-containing gene 18 protein

    See identical proteins and their annotated locations for NP_001073964.2

    Status: VALIDATED

    Source sequence(s)
    AB058759, AC092171, AC093376, AC093620, AI738451, BC029940, BC131808, BX396597, CN295035, CR993399, DN990416, DR159642, U80753
    Consensus CDS
    CCDS47534.1
    UniProtKB/Swiss-Prot
    O15417, Q96K91
    UniProtKB/TrEMBL
    A3KMH2
    Related
    ENSP00000395538.1, ENST00000430969.6
    Conserved Domains (3) summary
    PHA03247
    Location:22912531
    PHA03247; large tegument protein UL36; Provisional
    cd04714
    Location:28162960
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20469
    Location:22202286
    Tudor_TNRC18; Tudor domain found in trinucleotide repeat-containing gene 18 protein (TNRC18) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    5306811..5423834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012737.3XP_016868226.1  trinucleotide repeat-containing gene 18 protein isoform X9

  2. XM_047420983.1XP_047276939.1  trinucleotide repeat-containing gene 18 protein isoform X9

  3. XM_017012728.3XP_016868217.1  trinucleotide repeat-containing gene 18 protein isoform X1

  4. XM_047420978.1XP_047276934.1  trinucleotide repeat-containing gene 18 protein isoform X1

  5. XM_047420977.1XP_047276933.1  trinucleotide repeat-containing gene 18 protein isoform X1

  6. XM_017012736.2XP_016868225.1  trinucleotide repeat-containing gene 18 protein isoform X9

  7. XM_047420976.1XP_047276932.1  trinucleotide repeat-containing gene 18 protein isoform X1

  8. XM_017012732.2XP_016868221.1  trinucleotide repeat-containing gene 18 protein isoform X6

  9. XM_047420980.1XP_047276936.1  trinucleotide repeat-containing gene 18 protein isoform X4

  10. XM_017012730.2XP_016868219.1  trinucleotide repeat-containing gene 18 protein isoform X2

  11. XM_047420981.1XP_047276937.1  trinucleotide repeat-containing gene 18 protein isoform X8

  12. XM_017012731.2XP_016868220.1  trinucleotide repeat-containing gene 18 protein isoform X5

  13. XM_047420979.1XP_047276935.1  trinucleotide repeat-containing gene 18 protein isoform X3

    UniProtKB/Swiss-Prot
    Q96K91
    Conserved Domains (3) summary
    PHA03247
    Location:22912531
    PHA03247; large tegument protein UL36; Provisional
    cd04714
    Location:28162960
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20469
    Location:22202286
    Tudor_TNRC18; Tudor domain found in trinucleotide repeat-containing gene 18 protein (TNRC18) and similar proteins
  14. XM_017012734.3XP_016868223.1  trinucleotide repeat-containing gene 18 protein isoform X7

  15. XM_017012739.3XP_016868228.1  trinucleotide repeat-containing gene 18 protein isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    5424509..5541506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013722.1: Suppressed sequence

    Description
    NM_001013722.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.