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NTNG2 netrin G2 [ Homo sapiens (human) ]

Gene ID: 84628, updated on 1-Aug-2020

Summary

Official Symbol
NTNG2provided by HGNC
Official Full Name
netrin G2provided by HGNC
Primary source
HGNC:HGNC:14288
See related
Ensembl:ENSG00000196358 MIM:618689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Lmnt2; NTNG1; NEDBASH; LHLL9381; bA479K20.1
Expression
Biased expression in bone marrow (RPKM 7.5), brain (RPKM 4.1) and 4 other tissues See more
Orthologs

Genomic context

See NTNG2 in Genome Data Viewer
Location:
9q34.13
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (132161234..132244534)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135037334..135118224)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 27 Neighboring gene uncharacterized LOC105376302 Neighboring gene senataxin Neighboring gene Sharpr-MPRA regulatory region 6614

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
NEURODEVELOPMENTAL DISORDER WITH BEHAVIORAL ABNORMALITIES, ABSENT SPEECH, AND HYPOTONIA
MedGen: C5231471 OMIM: 618718 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0625, KIAA1857, MGC21884

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
basement membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
postsynaptic specialization assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Flemming body IDA
Inferred from Direct Assay
more info
 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
anchored component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
anchored component of presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
laminin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
netrin-G2
Names
bA479K20.1 (novel protein)
laminet 2
netrin G1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032536.4NP_115925.2  netrin-G2 precursor

    See identical proteins and their annotated locations for NP_115925.2

    Status: VALIDATED

    Source sequence(s)
    AL159997, AL353631, CK301008
    Consensus CDS
    CCDS6946.1
    UniProtKB/Swiss-Prot
    Q96CW9
    Related
    ENSP00000376921.3, ENST00000393229.4
    Conserved Domains (3) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:409456
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    132161234..132244534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519096.2XP_011517398.1  netrin-G2 isoform X1

    See identical proteins and their annotated locations for XP_011517398.1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  2. XM_017015213.1XP_016870702.1  netrin-G2 isoform X1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  3. XM_011519100.2XP_011517402.1  netrin-G2 isoform X1

    See identical proteins and their annotated locations for XP_011517402.1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  4. XM_011519099.2XP_011517401.1  netrin-G2 isoform X1

    See identical proteins and their annotated locations for XP_011517401.1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  5. XM_011519097.3XP_011517399.1  netrin-G2 isoform X1

    See identical proteins and their annotated locations for XP_011517399.1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  6. XM_011519094.2XP_011517396.1  netrin-G2 isoform X1

    See identical proteins and their annotated locations for XP_011517396.1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  7. XM_011519106.2XP_011517408.1  netrin-G2 isoform X2

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:492539
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:539569
    EGF_2; EGF-like domain
  8. XM_017015214.1XP_016870703.1  netrin-G2 isoform X3

  9. XM_006717304.3XP_006717367.1  netrin-G2 isoform X4

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:443490
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:490520
    EGF_2; EGF-like domain
  10. XM_011519107.2XP_011517409.1  netrin-G2 isoform X5

    See identical proteins and their annotated locations for XP_011517409.1

    UniProtKB/Swiss-Prot
    Q96CW9
    Conserved Domains (3) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:409456
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
  11. XM_011519098.2XP_011517400.1  netrin-G2 isoform X1

    See identical proteins and their annotated locations for XP_011517400.1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  12. XM_011519102.2XP_011517404.1  netrin-G2 isoform X1

    See identical proteins and their annotated locations for XP_011517404.1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  13. XM_011519108.2XP_011517410.1  netrin-G2 isoform X6

    Conserved Domains (2) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
  14. XM_011519109.2XP_011517411.1  netrin-G2 isoform X8

    Conserved Domains (2) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
  15. XM_011519110.2XP_011517412.1  netrin-G2 isoform X9

    Related
    ENSP00000361252.3, ENST00000372179.7
    Conserved Domains (2) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
  16. XM_017015216.1XP_016870705.1  netrin-G2 isoform X11

  17. XM_017015212.1XP_016870701.1  netrin-G2 isoform X1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  18. XM_011519105.2XP_011517407.1  netrin-G2 isoform X1

    See identical proteins and their annotated locations for XP_011517407.1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  19. XM_011519104.3XP_011517406.1  netrin-G2 isoform X1

    See identical proteins and their annotated locations for XP_011517406.1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  20. XM_011519103.2XP_011517405.1  netrin-G2 isoform X1

    See identical proteins and their annotated locations for XP_011517405.1

    Conserved Domains (4) summary
    cd00055
    Location:286332
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:515562
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:60285
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam07974
    Location:562592
    EGF_2; EGF-like domain
  21. XM_011519112.2XP_011517414.1  netrin-G2 isoform X10

    Conserved Domains (1) summary
    pfam00053
    Location:184231
    Laminin_EGF; Laminin EGF domain
  22. XM_011519113.2XP_011517415.1  netrin-G2 isoform X12

    Conserved Domains (1) summary
    pfam00053
    Location:161208
    Laminin_EGF; Laminin EGF domain
  23. XM_017015215.1XP_016870704.1  netrin-G2 isoform X7

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