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ST6GAL2 ST6 beta-galactoside alpha-2,6-sialyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 84620, updated on 2-Oct-2018

Summary

Official Symbol
ST6GAL2provided by HGNC
Official Full Name
ST6 beta-galactoside alpha-2,6-sialyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:10861
See related
Ensembl:ENSG00000144057 MIM:608472; Vega:OTTHUMG00000130923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAT2; ST6GalII
Summary
This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Expression
Biased expression in thyroid (RPKM 11.0), brain (RPKM 3.9) and 3 other tissues See more
Orthologs

Genomic context

See ST6GAL2 in Genome Data Viewer
Location:
2q12.3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (106801600..106887410, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (107418056..107503563, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724744 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 12 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 5 Neighboring gene uncharacterized LOC105373535

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30711, FLJ37730, FLJ38334, KIAA1877

Gene Ontology Provided by GOA

Process Evidence Code Pubs
oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
sialylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-galactoside alpha-2,6-sialyltransferase 2
Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
alpha 2,6-ST 2
beta-galactoside alpha-2,6-sialyltransferase II
sialyltransferase 2 (monosialoganglioside sialyltransferase)
NP_001135823.1
NP_001135824.1
NP_001309291.1
NP_115917.1
XP_006712865.1
XP_011510301.1
XP_011510302.1
XP_011510303.1
XP_016860599.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031986.1 RefSeqGene

    Range
    5001..90508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142351.1NP_001135823.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform a

    See identical proteins and their annotated locations for NP_001135823.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AB058780, AB059555, AC108049, BQ016989, CN365495
    Consensus CDS
    CCDS2073.1
    UniProtKB/Swiss-Prot
    Q96JF0
    Related
    ENSP00000386942.3, OTTHUMP00000203342, ENST00000409382.7, OTTHUMT00000330065
    Conserved Domains (1) summary
    pfam00777
    Location:278511
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001142352.1NP_001135824.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform b

    See identical proteins and their annotated locations for NP_001135824.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK307784, BC008680, DA176100
    Consensus CDS
    CCDS46380.1
    UniProtKB/Swiss-Prot
    Q96JF0
    Related
    ENSP00000387332.3, OTTHUMP00000203341, ENST00000409087.3, OTTHUMT00000330064
    Conserved Domains (1) summary
    pfam00777
    Location:278439
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_001322362.1NP_001309291.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC005040, AC016994, AC108049, R61253
    Consensus CDS
    CCDS2073.1
    UniProtKB/Swiss-Prot
    Q96JF0
    Conserved Domains (1) summary
    pfam00777
    Location:278511
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. NM_032528.2NP_115917.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform a

    See identical proteins and their annotated locations for NP_115917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB059555, AC108049, BQ016989, CN365495, DA176100
    Consensus CDS
    CCDS2073.1
    UniProtKB/Swiss-Prot
    Q96JF0
    Related
    ENSP00000355273.4, OTTHUMP00000161529, ENST00000361686.8, OTTHUMT00000253517
    Conserved Domains (1) summary
    pfam00777
    Location:278511
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_136313.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005040, AC016994, AC108049, R61253

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    106801600..106887410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511999.2XP_011510301.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011510301.1

    UniProtKB/Swiss-Prot
    Q96JF0
    Conserved Domains (1) summary
    pfam00777
    Location:278511
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_006712802.1XP_006712865.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006712865.1

    UniProtKB/Swiss-Prot
    Q96JF0
    Conserved Domains (1) summary
    pfam00777
    Location:278511
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_011512001.2XP_011510303.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X3

    See identical proteins and their annotated locations for XP_011510303.1

    UniProtKB/Swiss-Prot
    Q96JF0
    Conserved Domains (1) summary
    pfam00777
    Location:278439
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_017005110.1XP_016860599.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X4

  5. XM_011512000.2XP_011510302.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:278442
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_923046.2 RNA Sequence

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