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KLF11 Kruppel like factor 11 [ Homo sapiens (human) ]

Gene ID: 8462, updated on 12-May-2019

Summary

Official Symbol
KLF11provided by HGNC
Official Full Name
Kruppel like factor 11provided by HGNC
Primary source
HGNC:HGNC:11811
See related
Ensembl:ENSG00000172059 MIM:603301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKLF; FKLF1; MODY7; TIEG2; Tieg3
Summary
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in testis (RPKM 20.2), lung (RPKM 12.4) and 25 other tissues See more
Orthologs

Genomic context

See KLF11 in Genome Data Viewer
Location:
2p25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (10043555..10054836)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (10170776..10194963)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268412 Neighboring gene uncharacterized LOC101929882 Neighboring gene cystin 1 Neighboring gene ribonucleotide reductase regulatory subunit M2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from BioSystems

  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe functional B-cell receptor is a multi-protein complex consisting of an antigen binding subunit and a signaling subunit. The antigen binding subunit is the membrane bound immunoglobulin and the si...
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 11
Names
TGFB-inducible early growth response protein 2
TIEG-2
transforming growth factor-beta-inducible early growth response protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017199.1 RefSeqGene

    Range
    5001..16282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177716.1NP_001171187.1  Krueppel-like factor 11 isoform b

    See identical proteins and their annotated locations for NP_001171187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC104794, AI755210, AK316439, BC063286
    Consensus CDS
    CCDS54333.1
    UniProtKB/Swiss-Prot
    O14901
    UniProtKB/TrEMBL
    B7ZAX4
    Related
    ENSP00000444690.1, ENST00000540845.5
    Conserved Domains (4) summary
    COG5048
    Location:376432
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:437459
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:423446
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001177718.1NP_001171189.1  Krueppel-like factor 11 isoform b

    See identical proteins and their annotated locations for NP_001171189.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC104794, AI755210, BC063286, BC074922, BG701929
    Consensus CDS
    CCDS54333.1
    UniProtKB/Swiss-Prot
    O14901
    Related
    ENSP00000442722.1, ENST00000535335.1
    Conserved Domains (4) summary
    COG5048
    Location:376432
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:437459
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:423446
    zf-H2C2_2; Zinc-finger double domain
  3. NM_003597.5NP_003588.1  Krueppel-like factor 11 isoform a

    See identical proteins and their annotated locations for NP_003588.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC104794
    Consensus CDS
    CCDS1668.1
    UniProtKB/Swiss-Prot
    O14901
    UniProtKB/TrEMBL
    Q53QU8
    Related
    ENSP00000307023.1, ENST00000305883.6
    Conserved Domains (4) summary
    COG5048
    Location:393449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:399418
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:454476
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:440463
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    10043555..10054836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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