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TUBB6 tubulin beta 6 class V [ Homo sapiens (human) ]

Gene ID: 84617, updated on 7-Jun-2020

Summary

Official Symbol
TUBB6provided by HGNC
Official Full Name
tubulin beta 6 class Vprovided by HGNC
Primary source
HGNC:HGNC:20776
See related
Ensembl:ENSG00000176014 MIM:615103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPVEPD; TUBB-5; HsT1601
Expression
Ubiquitous expression in fat (RPKM 41.4), esophagus (RPKM 38.3) and 25 other tissues See more
Orthologs

Genomic context

See TUBB6 in Genome Data Viewer
Location:
18p11.21
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (12307669..12329826)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12308218..12326568)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1751 Neighboring gene RNA, U6 small nuclear 170, pseudogene Neighboring gene uncharacterized LOC107985154 Neighboring gene AFG3 like matrix AAA peptidase subunit 2 Neighboring gene RNA, U7 small nuclear 129 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev Rev acts to depolymerize microtubules that are formed by tubulin, an effect that is observed during HIV-1 infection PubMed
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
tat HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4083, MGC132410

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
tubulin beta-6 chain
Names
class V beta-tubulin
tubulin beta MGC4083
tubulin beta class V
tubulin, beta 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303524.1NP_001290453.1  tubulin beta-6 chain isoform 1

    See identical proteins and their annotated locations for NP_001290453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK001295, CD364877, DB271698
    Consensus CDS
    CCDS11858.1
    UniProtKB/Swiss-Prot
    Q9BUF5
    Conserved Domains (1) summary
    PLN00220
    Location:1432
    PLN00220; tubulin beta chain; Provisional
  2. NM_001303525.1NP_001290454.1  tubulin beta-6 chain isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5'-terminal exon compared to variant 1. This results in a novel 3' coding region and 3' UTR. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK001295, BC039717, CX866060
    Consensus CDS
    CCDS77153.1
    UniProtKB/Swiss-Prot
    Q9BUF5
    UniProtKB/TrEMBL
    K7EJ64
    Related
    ENSP00000465040.1, ENST00000591909.5
    Conserved Domains (1) summary
    cl25946
    Location:193
    Tubulin; Tubulin/FtsZ family, GTPase domain
  3. NM_001303526.2NP_001290455.1  tubulin beta-6 chain isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter compared to isoform 1.
    Source sequence(s)
    AK001295, BP268791, CD364877, CX866060
    UniProtKB/Swiss-Prot
    Q9BUF5
    Related
    ENSP00000468777.1, ENST00000590103.5
    Conserved Domains (2) summary
    PLN00220
    Location:1395
    PLN00220; tubulin beta chain; Provisional
    cd02187
    Location:2389
    beta_tubulin; The beta-tubulin family
  4. NM_001303527.2NP_001290456.1  tubulin beta-6 chain isoform 4

    See identical proteins and their annotated locations for NP_001290456.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in its 5' UTR and uses a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK001295, CD364877, CN367565, CX866060
    UniProtKB/Swiss-Prot
    Q9BUF5
    UniProtKB/TrEMBL
    B3KS31
    Conserved Domains (1) summary
    PLN00220
    Location:1360
    PLN00220; tubulin beta chain; Provisional
  5. NM_001303528.2NP_001290457.1  tubulin beta-6 chain isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate internal exon, which results in a distinct 5' UTR and the use of an alternate start codon, compared to variant 1. The encoded isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK001295, AP005264, CD364877, DA693982
    UniProtKB/Swiss-Prot
    Q9BUF5
    Conserved Domains (2) summary
    PLN00220
    Location:28367
    PLN00220; tubulin beta chain; Provisional
    cd02187
    Location:28361
    beta_tubulin; The beta-tubulin family
  6. NM_001303529.2NP_001290458.1  tubulin beta-6 chain isoform 6

    See identical proteins and their annotated locations for NP_001290458.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 3'-terminal exon compared to variant 1. This results in a distinct 5' UTR and the use of a downstream in-frame start codon. The encoded isoform (6) has a shorter N-terminus compared to isoform 1. Both variants 7 and 8 encode the same isoform.
    Source sequence(s)
    AK001295, AK311364, CD364877, CX866060, DA765796
    UniProtKB/Swiss-Prot
    Q9BUF5
    UniProtKB/TrEMBL
    B4E386
    Conserved Domains (1) summary
    PLN00220
    Location:1286
    PLN00220; tubulin beta chain; Provisional
  7. NM_001303530.2NP_001290459.1  tubulin beta-6 chain isoform 6

    See identical proteins and their annotated locations for NP_001290459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate exon in its 5' UTR and uses an alternate splice site in the 3'-terminal exon, compared to variant 1. This results in a distinct 5' UTR and the use of a downstream in-frame start codon. The encoded isoform (6) has a shorter N-terminus compared to isoform 1. Both variants 7 and 8 encode the same isoform.
    Source sequence(s)
    AK001295, AK311364, AP005264, CD364877
    UniProtKB/Swiss-Prot
    Q9BUF5
    UniProtKB/TrEMBL
    B4E386
    Conserved Domains (1) summary
    PLN00220
    Location:1286
    PLN00220; tubulin beta chain; Provisional
  8. NM_032525.3NP_115914.1  tubulin beta-6 chain isoform 1

    See identical proteins and their annotated locations for NP_115914.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK001295, CD364877
    Consensus CDS
    CCDS11858.1
    UniProtKB/Swiss-Prot
    Q9BUF5
    Related
    ENSP00000318697.4, ENST00000317702.10
    Conserved Domains (1) summary
    PLN00220
    Location:1432
    PLN00220; tubulin beta chain; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    12307669..12329826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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