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ZBTB37 zinc finger and BTB domain containing 37 [ Homo sapiens (human) ]

Gene ID: 84614, updated on 13-Apr-2025

Summary

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Official Symbol
ZBTB37provided by HGNC
Official Full Name
zinc finger and BTB domain containing 37provided by HGNC
Primary source
HGNC:HGNC:28365
See related
Ensembl:ENSG00000185278 AllianceGenome:HGNC:28365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF908; D430004I08Rik
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in chromatin. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in testis (RPKM 2.8), bone marrow (RPKM 1.4) and 24 other tissues See more
Orthologs
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Genomic context

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See ZBTB37 in Genome Data Viewer
Location:
1q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173868082..173903547)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (173226202..173261663)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173837220..173872685)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173837597-173838796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2118 Neighboring gene growth arrest specific 5 Neighboring gene small nucleolar RNA, C/D box 75 Neighboring gene small nucleolar RNA, C/D box 74 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173863193-173864392 Neighboring gene serpin family C member 1 Neighboring gene uncharacterized LOC124904457 Neighboring gene RNA, 5S ribosomal pseudogene 67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. Thalappilly S, et al. Proteomics, 2008 Aug. PMID 18654987
  2. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Katsogiannou M, et al. Mol Cell Proteomics, 2014 Dec. PMID 25277244, Free PMC Article
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061
  5. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC2629

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122770.3 → NP_001116242.1  zinc finger and BTB domain-containing protein 37 isoform a

    See identical proteins and their annotated locations for NP_001116242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL136170, KF455104
    Consensus CDS
    CCDS44278.1
    UniProtKB/Swiss-Prot
    Q5TC79, Q5TC80, Q96M87, Q9BQ88
    UniProtKB/TrEMBL
    B7Z7Z4
    Related
    ENSP00000356674.4, ENST00000367701.10
    Conserved Domains (4) summary
    sd00017
    Location:375 → 395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:401 → 423
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:416 → 438
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001346115.2 → NP_001333044.1  zinc finger and BTB domain-containing protein 37 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the C-terminus compared to isoform a.
    Source sequence(s)
    AL136170, KF455104
    Consensus CDS
    CCDS86033.1
    UniProtKB/Swiss-Prot
    Q5TC79
    UniProtKB/TrEMBL
    B7Z7Z4
    Conserved Domains (1) summary
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  3. NM_001369846.1 → NP_001356775.1  zinc finger and BTB domain-containing protein 37 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL136170, KF455104
    Consensus CDS
    CCDS86033.1
    Related
    ENSP00000356677.1, ENST00000367704.5
    Conserved Domains (1) summary
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  4. NM_001395199.1 → NP_001382128.1  zinc finger and BTB domain-containing protein 37 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL136170, KF455104
    Consensus CDS
    CCDS44278.1
    UniProtKB/Swiss-Prot
    Q5TC79, Q5TC80, Q96M87, Q9BQ88
    UniProtKB/TrEMBL
    B7Z7Z4
    Related
    ENSP00000511931.1, ENST00000695459.1
    Conserved Domains (4) summary
    sd00017
    Location:375 → 395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:401 → 423
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:416 → 438
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001395200.1 → NP_001382129.1  zinc finger and BTB domain-containing protein 37 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL136170
    Conserved Domains (1) summary
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  6. NM_001395201.1 → NP_001382130.1  zinc finger and BTB domain-containing protein 37 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL136170
    Conserved Domains (1) summary
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  7. NM_001395202.1 → NP_001382131.1  zinc finger and BTB domain-containing protein 37 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL136170
    Conserved Domains (1) summary
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  8. NM_032522.5 → NP_115911.1  zinc finger and BTB domain-containing protein 37 isoform b

    See identical proteins and their annotated locations for NP_115911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL136170, KF455104
    Consensus CDS
    CCDS1312.1
    UniProtKB/Swiss-Prot
    Q5TC79
    Related
    ENSP00000356675.1, ENST00000367702.1
    Conserved Domains (1) summary
    pfam00651
    Location:22 → 122
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    173868082..173903547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002557.2 → XP_016858046.1  zinc finger and BTB domain-containing protein 37 isoform X2

    UniProtKB/Swiss-Prot
    Q5TC79
    Conserved Domains (1) summary
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  2. XM_011510062.4 → XP_011508364.1  zinc finger and BTB domain-containing protein 37 isoform X2

    See identical proteins and their annotated locations for XP_011508364.1

    UniProtKB/Swiss-Prot
    Q5TC79
    Conserved Domains (1) summary
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  3. XM_006711578.5 → XP_006711641.1  zinc finger and BTB domain-containing protein 37 isoform X1

    See identical proteins and their annotated locations for XP_006711641.1

    UniProtKB/Swiss-Prot
    Q5TC79, Q5TC80, Q96M87, Q9BQ88
    UniProtKB/TrEMBL
    B7Z7Z4
    Conserved Domains (4) summary
    sd00017
    Location:375 → 395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:401 → 423
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:416 → 438
    zf-H2C2_2; Zinc-finger double domain

  4. XM_047432197.1 → XP_047288153.1  zinc finger and BTB domain-containing protein 37 isoform X2

  5. XM_017002558.2 → XP_016858047.1  zinc finger and BTB domain-containing protein 37 isoform X3

    UniProtKB/Swiss-Prot
    Q5TC79
    Conserved Domains (1) summary
    cd18222
    Location:7 → 129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    173226202..173261663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339219.1 → XP_054195194.1  zinc finger and BTB domain-containing protein 37 isoform X2

  2. XM_054339218.1 → XP_054195193.1  zinc finger and BTB domain-containing protein 37 isoform X2

  3. XM_054339217.1 → XP_054195192.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/Swiss-Prot
    Q5TC79, Q5TC80, Q96M87, Q9BQ88
    UniProtKB/TrEMBL
    B7Z7Z4

  4. XM_054339221.1 → XP_054195196.1  zinc finger and BTB domain-containing protein 37 isoform X2

  5. XM_054339220.1 → XP_054195195.1  zinc finger and BTB domain-containing protein 37 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TC79.1 GenPept UniProtKB/Swiss-Prot:Q5TC79

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