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ZBTB37 zinc finger and BTB domain containing 37 [ Homo sapiens (human) ]

Gene ID: 84614, updated on 1-Jun-2020

Summary

Official Symbol
ZBTB37provided by HGNC
Official Full Name
zinc finger and BTB domain containing 37provided by HGNC
Primary source
HGNC:HGNC:28365
See related
Ensembl:ENSG00000185278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF908; D430004I08Rik
Expression
Broad expression in testis (RPKM 2.8), bone marrow (RPKM 1.4) and 24 other tissues See more
Orthologs

Genomic context

See ZBTB37 in Genome Data Viewer
Location:
1q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (173868082..173903547)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173837220..173856596)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 75 Neighboring gene small nucleolar RNA, C/D box 74 Neighboring gene growth arrest specific 5 Neighboring gene serpin family C member 1 Neighboring gene RNA, 5S ribosomal pseudogene 67 Neighboring gene ring finger and CCCH-type domains 1 Neighboring gene RNA, 5S ribosomal pseudogene 68

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC2629

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122770.3NP_001116242.1  zinc finger and BTB domain-containing protein 37 isoform a

    See identical proteins and their annotated locations for NP_001116242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL136170, KF455104
    Consensus CDS
    CCDS44278.1
    UniProtKB/Swiss-Prot
    Q5TC79
    UniProtKB/TrEMBL
    B7Z7Z4
    Conserved Domains (5) summary
    PHA00733
    Location:374456
    PHA00733; hypothetical protein
    sd00017
    Location:375395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:401423
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:22122
    BTB; BTB/POZ domain
    pfam13465
    Location:416438
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001346115.2NP_001333044.1  zinc finger and BTB domain-containing protein 37 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the C-terminus compared to isoform a.
    Source sequence(s)
    AL136170, KF455104
    Consensus CDS
    CCDS86033.1
    UniProtKB/Swiss-Prot
    Q5TC79
    UniProtKB/TrEMBL
    B7Z7Z4
    Conserved Domains (1) summary
    cd18222
    Location:7129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
  3. NM_001369846.1NP_001356775.1  zinc finger and BTB domain-containing protein 37 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL136170, KF455104
    Related
    ENSP00000356677.1, ENST00000367704.5
    Conserved Domains (1) summary
    cd18222
    Location:7129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
  4. NM_032522.5NP_115911.1  zinc finger and BTB domain-containing protein 37 isoform b

    See identical proteins and their annotated locations for NP_115911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL136170, KF455104
    Consensus CDS
    CCDS1312.1
    UniProtKB/Swiss-Prot
    Q5TC79
    Related
    ENSP00000356675.1, ENST00000367702.1
    Conserved Domains (1) summary
    pfam00651
    Location:22122
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    173868082..173903547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711578.4XP_006711641.1  zinc finger and BTB domain-containing protein 37 isoform X1

    See identical proteins and their annotated locations for XP_006711641.1

    UniProtKB/Swiss-Prot
    Q5TC79
    Conserved Domains (5) summary
    PHA00733
    Location:374456
    PHA00733; hypothetical protein
    sd00017
    Location:375395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:401423
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:22122
    BTB; BTB/POZ domain
    pfam13465
    Location:416438
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011510062.3XP_011508364.1  zinc finger and BTB domain-containing protein 37 isoform X2

    See identical proteins and their annotated locations for XP_011508364.1

    UniProtKB/Swiss-Prot
    Q5TC79
    Conserved Domains (1) summary
    cd18222
    Location:7129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
  3. XM_017002558.1XP_016858047.1  zinc finger and BTB domain-containing protein 37 isoform X3

    UniProtKB/Swiss-Prot
    Q5TC79
    Conserved Domains (1) summary
    cd18222
    Location:7129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
  4. XM_024450302.1XP_024306070.1  zinc finger and BTB domain-containing protein 37 isoform X1

    Related
    ENSP00000415293.1, ENST00000427304.5
    Conserved Domains (5) summary
    PHA00733
    Location:374456
    PHA00733; hypothetical protein
    sd00017
    Location:375395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:401423
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:22122
    BTB; BTB/POZ domain
    pfam13465
    Location:416438
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017002557.2XP_016858046.1  zinc finger and BTB domain-containing protein 37 isoform X2

    UniProtKB/Swiss-Prot
    Q5TC79
    Conserved Domains (1) summary
    cd18222
    Location:7129
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
  6. XM_017002556.2XP_016858045.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/Swiss-Prot
    Q5TC79
    Related
    ENSP00000356674.4, ENST00000367701.9
    Conserved Domains (5) summary
    PHA00733
    Location:374456
    PHA00733; hypothetical protein
    sd00017
    Location:375395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:401423
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:22122
    BTB; BTB/POZ domain
    pfam13465
    Location:416438
    zf-H2C2_2; Zinc-finger double domain
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