Format

Send to:

Choose Destination

PARD6B par-6 family cell polarity regulator beta [ Homo sapiens (human) ]

Gene ID: 84612, updated on 29-Mar-2020

Summary

Official Symbol
PARD6Bprovided by HGNC
Official Full Name
par-6 family cell polarity regulator betaprovided by HGNC
Primary source
HGNC:HGNC:16245
See related
Ensembl:ENSG00000124171 MIM:608975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAR6B
Summary
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 9.5), lung (RPKM 3.4) and 17 other tissues See more
Orthologs

Genomic context

See PARD6B in Genome Data Viewer
Location:
20q13.13
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (50731580..50753741)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49347923..49373333)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RIPOR family member 3 Neighboring gene VISTA enhancer hs1860 Neighboring gene CRISPRi-validated cis-regulatory element chr20.2420 Neighboring gene breast carcinoma amplified sequence 4 Neighboring gene TMSB4X pseudogene 6 Neighboring gene activity dependent neuroprotector homeobox Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axonogenesis TAS
Traceable Author Statement
more info
PubMed 
bicellular tight junction assembly TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction assembly TAS
Traceable Author Statement
more info
PubMed 
centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
regulation of cellular localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
partitioning defective 6 homolog beta
Names
PAR-6 beta
par-6 partitioning defective 6 homolog beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032521.3NP_115910.1  partitioning defective 6 homolog beta

    See identical proteins and their annotated locations for NP_115910.1

    Status: REVIEWED

    Source sequence(s)
    AB044555, AL031680, BC060847, CA435324
    Consensus CDS
    CCDS33485.1
    UniProtKB/Swiss-Prot
    Q9BYG5
    Related
    ENSP00000360672.2, ENST00000371610.7
    Conserved Domains (2) summary
    cd06403
    Location:1796
    PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
    cd00992
    Location:156247
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    50731580..50753741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center