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Jak1 Janus kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84598, updated on 8-Jul-2021

Summary

Official Symbol
Jak1provided by RGD
Official Full Name
Janus kinase 1provided by RGD
Primary source
RGD:69056
See related
Ensembl:ENSRNOG00000011157
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
protein-tyrosine kinases; involved in intracellular signal transduction [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 855.0), Spleen (RPKM 452.2) and 9 other tissues See more
Orthologs
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Genomic context

See Jak1 in Genome Data Viewer
Location:
5q33
Exon count:
28
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (115780248..115888841, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (119982503..120091452, complement)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene cache domain containing 1 Neighboring gene uncharacterized LOC120102932 Neighboring gene ribonucleoprotein, PTB-binding 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120102933 Neighboring gene small nucleolar RNA SNORA70

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables CCR5 chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to interleukin-3 ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interleukin-7 ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within enzyme linked receptor protein signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-2-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein kinase JAK1
Names
Janus protein tyrosine kinase 1
NP_445918.1
XP_006238514.1
XP_006238515.1
XP_038966807.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053466.1NP_445918.1  tyrosine-protein kinase JAK1

    See identical proteins and their annotated locations for NP_445918.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473998
    UniProtKB/TrEMBL
    G3V9W2
    Related
    ENSRNOP00000061649.1, ENSRNOT00000064542.1
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    smart00295
    Location:37286
    B41; Band 4.1 homologues
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:8741146
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    115780248..115888841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238452.4XP_006238514.1  tyrosine-protein kinase JAK1 isoform X1

    See identical proteins and their annotated locations for XP_006238514.1

    UniProtKB/TrEMBL
    G3V9W2
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    smart00295
    Location:37286
    B41; Band 4.1 homologues
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:8741146
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_006238453.4XP_006238515.1  tyrosine-protein kinase JAK1 isoform X1

    See identical proteins and their annotated locations for XP_006238515.1

    UniProtKB/TrEMBL
    G3V9W2
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    smart00295
    Location:37286
    B41; Band 4.1 homologues
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:8741146
    Pkinase_Tyr; Protein tyrosine kinase
  3. XM_039110879.1XP_038966807.1  tyrosine-protein kinase JAK1 isoform X2

    Conserved Domains (6) summary
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam18377
    Location:147277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:52129
    FERM_F1; FERM F1 ubiquitin-like domain
    cl21453
    Location:869957
    PKc_like; Protein Kinases, catalytic domain
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